MRI and F-BPA PET-guided targeting in boron neutron capture therapy.

In modern Boron neutron capture therapy (BNCT) treatment planning, F-BPA (F-boronophenylalanine) PET (positron emission tomography) imaging is used to assess boron uptake and guide accurate dose delivery. This study evaluates the geometric and dosimetric differences between target volumes defined by MRI (magnetic resonance imaging) and PET images in accelerator-based BNCT using the NeuPex system. The GTV (gross tumor volume) was defined based on MRI (GTV) and PET images with SUV thresholds of 2.

Application of a proven treatment planning system for accelerator-based boron neutron capture therapy.

This study introduces NeuMANTA (Multifunctional Arithmetic for Neutron Transportation Analysis), a dedicated treatment planning system (TPS) developed for accelerator-based boron neutron capture therapy (AB-BNCT). NeuMANTA integrates Monte Carlo-based dose calculation with modular workflow management to enable full-cycle support from imaging to post-treatment verification. Powered by the BNCT-specific COMPASS (COMpact PArticle Simulation System) engine, the system achieves dosimetric accuracy comparable to MCNP while reducing computation time by 2.