Publications by authors named "Xiangyun Dou"
Safety issues of tofacitinib in rheumatoid arthritis patients: real-world pharmacovigilance.
Expert Opin Drug Saf
July 2025
Background: Tofacitinib is the first oral tsDMARD approved for the treatment of rheumatoid arthritis, often used as monotherapy or in combination with conventional synthetic DMARDs. However, its safety profile has yet to be systematically evaluated. Our study is the largest pharmacovigilance analysis of real-world data on the safety of tofacitinib.
View Article and Find Full Text PDFAdverse events associated with carbamazepine: a pharmacovigilance study using the FDA Adverse Event Reporting System.
Expert Opin Drug Saf
October 2024
Article Synopsis
- Carbamazepine (CBZ) is a widely used medication for epilepsy, but its side effects can complicate treatment, prompting the need for more in-depth studies on adverse drug reactions (ADRs).
- The research utilized the FDA Adverse Event Reporting System (FAERS) database to analyze CBZ-related ADRs, employing various risk detection methods while considering patient demographics like sex and age.
- Findings revealed that common ADRs included hereditary disorders and infections, with notable risks such as bone metabolism issues and ocular problems that are often underreported, highlighting the need for better monitoring and alternative treatment options for high-risk patients.
Safety of TNF-α inhibitors: A real-world study based on the US FDA Adverse Event Reporting System Database.
Medicine (Baltimore)
July 2024
Article Synopsis
- - This study investigates the adverse drug events (ADEs) linked to TNF-α inhibitors (TNFis) used in rheumatoid arthritis (RA) patients, pulling data from the FDA's reporting system to enhance clinical understanding.
- - Four common ADEs among TNFis are identified (pulmonary tuberculosis, infections, hypersensitivity, and herpes zoster), but each TNFi also has unique ADEs: Adalimumab has the highest with 63 unique events, while etanercept has 180 unique ADEs.
- - The research highlights the need for careful medication selection by clinicians, especially for RA patients with existing malignancies, due to the variety of common and unique ADEs linked to different TNFis.
Vitamin K2 (VK2) is an effective compound for anti-ferroptosis and anti-osteoporosis, and Semen sojae praeparatum (Dandouchi in Chinese) is the main source of VK2. Chondrocyte ferroptosis and extracellular matrix (ECM) degradation playing a role in the pathogenesis of osteoarthritis (OA). Glutathione peroxidase 4 (GPX4) is the intersection of two mechanisms in regulating OA progression.
View Article and Find Full Text PDFAdverse tumor events induced by ranitidine: an analysis based on the FAERS database.
Expert Opin Drug Saf
January 2025
Background: Ranitidine induced tumor adverse events remains a contradictory clinical question, due to the limited evidence of tumor risk associated with ranitidine in the real world. The purpose of this study was to evaluate the association of ranitidine with all types of tumors through the FAERS database and to provide a reference for clinical use.
Research Design And Methods: Cancer cases associated with ranitidine in the FAERS database from the first quarter of 2004 to the fourth quarter of 2023 were extracted to analyze demographic characteristics, and a disproportion analysis was performed.
Iron homeostasis plays an essential role in joint health, while iron overload can cause damage and death of cartilage cells. Cardamonin (CAR) is a substance found in the fruit of the chasteberry plant and has anti-inflammatory and anti-tumor activities. We first administered iron dextran (500 mg/kg) intraperitoneally to establish an iron overload mouse model and surgically induced osteoarthritis.
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