[Spatial Spillover Effect and Driving Factors of High-quality Energy Development in China].

High-quality energy development is an important part of high-quality economic development， which is important for realizing the 'dual-carbon' goal and combating climate change. Here， we construct a comprehensive evaluation index system for high-quality energy development in five dimensions： innovation， coordination， greenness， openness， and sharing， and measure China's high-quality energy development level from 2011 to 2021 based on the entropy method. Kernel density estimation， spatial autocorrelation， and spatial Markov chains are used to characterize the spatial and temporal evolution of the level of high-quality energy development， and the driving factors are explored with the help of Tobit regression models.

GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma.

Background: While previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to discover if GLUT1 promotes tumor progression through a non-metabolic pathway.

Methods: The RNA-seq and microarray data were comprehensively analyzed to evaluate the significance of GLUT1 expression in lung adenocarcinoma (LUAD). The cell proliferation, colony formation, invasion, and migration were used to test GLUT1 's oncogenic function.

Distribution characteristics and influencing factors of household consumption carbon emissions in China from a spatial perspective.

Household consumption carbon emissions (HCCEs) have become the main growth point of China's carbon emissions in the future. It is important to investigate the factors affecting the demand-side carbon emissions in order to find the accurate entry point of emission reduction and achieve carbon peaking and carbon neutrality goals. Different from previous studies, this study analyzed the spatial and temporal evolution characteristics of provincial HCCEs in China from a spatial perspective by using the Theil index and spatial auto-correlation and explored the key influencing factors and spatial spillover effects of HCCEs in different regions by using an econometric model.

Empirical research on household consumption carbon emissions and key impact factors in urban and rural China.

The analysis of household consumption carbon emissions (HCCEs), a significant source of CO emissions, is essential to achieving China's carbon peak before 2030 and carbon neutrality before 2060. Based on the calculation of urban and rural HCCEs during 2005-2019, the differences between urban and rural areas, spatial-temporal pattern and agglomeration characteristics of HCCEs were analyzed, and the panel quantile STIRPAT model was constructed to empirically test the influence of socioeconomic factors on urban and rural HCCEs at different quantile levels. The results indicate that, first, China's HCCEs are generally growing, indirect HCCEs are more than direct HCCEs, urban HCCEs are far more than rural, and the gap has a growing trend.

Evaluation of the Social Effects of Enterprise Carbon Accounts Based on Variable Weight CFPR Fuzzy VIKOR.

The carbon account is a digital path for an enterprise to achieve low-carbon transformation and high-quality sustainable development under the 'dual carbon' strategy. The carbon account has a good social effect while generating economic benefits. An evaluation index system of the social effects of enterprise carbon accounts has been established, including the concepts of energy conservation and carbon reduction, contributions, technological innovation, and customer trust.

In-vitro antiviral activity of doxepin hydrochloride against group B coxsackievirus.

Group B coxsackievirus is an enterovirus that can cause a variety of diseases, including myocarditis, aseptic meningitis, and hand, foot, and mouth disease. Currently, there is no effective antiviral drug against this virus. In this study, we used a cytopathic effect-based viral inhibition assay to screen an FDA-approved drug library and found that doxepin hydrochloride had potential antiviral activity.

Two Sets of Compound Complex Driving for High Efficiency of Nonintegration Reprogramming of Human Fibroblasts.

Currently, plentiful chemical-assisted methods have been applied for mouse induced pluripotent stem cells (iPSCs). It has been reported that small-molecule compounds can only reprogram mouse embryonic fibroblasts into mouse chemically induced pluripotent stem cells (mouse CiPSCs). However, human CiPSCs have not been reported.

Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells.

Unlabelled: We established an efficient strategy to direct human pluripotent stem cells, including human embryonic stem cells (hESCs) and an induced pluripotent stem cell (iPSC) line derived from patients with cystic fibrosis, to differentiate into pancreatic ductal epithelial cells (PDECs). After purification, more than 98% of hESC-derived PDECs expressed functional cystic fibrosis transmembrane conductance regulator (CFTR) protein. In addition, iPSC lines were derived from a patient with CF carrying compound frameshift and mRNA splicing mutations and were differentiated to PDECs.

A chemical platform for improved induction of human iPSCs.

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.