[Study on molecular target promoting human neural stem cells of ginsenoside Rg1 by gene chip].

Objective: To screen out main molecular target promoting human neural stem cells (NSCs) of ginsenoside Rg1 by using the gene chip technology.

Method: First, MTT assay was adopted to screen out the optimal concentration of Rg1-promoted NSC proliferation (120 mg x L(-1)). Then, on the 7th day after the Rg1-promoted NSC proliferation, the expression of target genes was observed by the gene chip technology.

[Effect of ginsenoside Rg1 on functional expression of human neural stem cells: a patch clamp study].

Objective: To observe the effects of ginsenoside Rg1 on the functional expression of human neural stem cells (hNSCs).

Method: The membrane electrophysiological properties and sodium and potassium ion channels in the hNSCs induced by Rg1 were analyzed using the whole-cell patch-clamp.

Result: On the 7th day, the neuron-like cells derived from ginsenoside Rg1 (20 mg x L(-1))-induced NSCs show: (1) The resting membrane potential: (-45.