Butyrate derived from intratumoral microbiome facilitates pulmonary metastasis in osteosarcoma.

Osteosarcoma, the predominant primary malignant bone tumor, has a dismal prognosis due to pulmonary metastasis, necessitating innovative strategies for early prediction and targeted therapy. While microbial metabolites such as butyrate are increasingly recognized as cancer modulators, their mechanistic involvement in osteosarcoma metastasis remains undefined. Here, we integrated multiomics integration of 16S rRNA sequencing and circulating microbial DNA (cmDNA) profiling to investigate intratumoral microbiome dynamics in osteosarcoma pulmonary metastasis.

Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism.

Skin fibrosis, characterized by uncontrolled secretion of extracellular matrix (ECM) proteins such as collagen, can lead to excessive scarring and compromised tissue function. Despite the widespread occurrence of fibrotic diseases, effective therapies are lacking. Recent clinical studies have demonstrated a positive correlation between serum homocysteine (Hcy) levels and the severity of systemic sclerosis.