Diagnostic Superiority of Transperineal Combined Fusion Biopsy Versus Transrectal Ultrasound-Guided Biopsy: Lower Upgrading Rates and Better Concordance with Post-Surgical Histopathology.

Accurate histopathological grading of prostate cancer at the time of biopsy is essential for guiding treatment decisions and minimizing the risks of both overtreatment and undertreatment. A key challenge in prostate cancer diagnostics is the phenomenon of upgrading, wherein the cancer appears more aggressive in the radical prostatectomy specimen than initially indicated by biopsy. Such discrepancies can compromise therapeutic planning.

Advances and Challenges in Prostate Cancer Diagnosis: A Comprehensive Review.

Prostate cancer is the most commonly diagnosed malignancy in men and continues to be a leading cause of cancer-related mortality. Accurate and timely diagnosis is essential for distinguishing clinically significant tumors from indolent lesions and for informing treatment decisions. Multiparametric magnetic resonance imaging (mpMRI) has revolutionized prostate cancer detection by enabling precise lesion localization, risk stratification, and improved biopsy targeting.

The role of computed tomography in post-mortem examinations.

In the study, data from the literature regarding the use of computed tomography in post-mortem examinations (post-mortem computed tomography - PMCT) were analyzed. Literature data indicate that PMCT should be used as a complementary tool rather than an alternative to autopsy, detecting additional changes that may have been unnoticed due to anatomical location or the need to extend traditional autopsy techniques. The ability to save, create and reconstruct images is very helpful in creating documentation and final opinions.