Fractionation and biological evaluation of passion fruit Pectins: HG and RG-I backbone ratios are associated with TLR2-1 interaction and signaling.

Passion fruit mesocarp is rich in pectin, and high-temperature/pressure modification of this pectin has been shown to yield bioactive fragments with anticancer potential. To clarify the structure-function relationship of passion fruit pectins, we purified native and modified pectins using two fractionation methods. Comprehensive chemical characterization revealed molecular weight as the primary difference between fractions, along with varying proportions of homogalacturonan (HG) and rhamnogalacturonan-I (RG-I).

Screening for Antileukemia Agents in FMS-like Tyrosine Kinase 3 (FLT3)-Mutated Acute Myeloid Leukemia Cells.

Acute myeloid leukemia (AML) remains a challenging hematological malignancy due to its genetic heterogeneity, high relapse rates, and limited therapeutic options for refractory cases. FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (FLT3-ITD) mutations are among the most frequent genetic alterations in AML, associated with poor prognosis and treatment resistance. In this study, we investigated the antileukemic potential of compound HI042, identified from a library of 78 molecules, focusing on its effects on FLT3-ITD-mutated AML models.

Convergent QSAR Models for the Prediction of Cruzain Inhibitors.

Chagas disease is a parasitosis caused by . Cruzain, the major cysteine protease from , is an excellent therapeutic target in the search for antichagasic drugs. It is important in the role of cell invasion, replication, differentiation, and metabolism of the parasite.

Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets.

Introduction: Chagas disease (CD) imposes social and economic burdens, yet the available treatments have limited efficacy in the disease's chronic phase and cause serious adverse effects. To address this challenge, target-based approaches are a possible strategy to develop new, safe, and active treatments for both phases of the disease.

Areas Covered: This review delves into target-based approaches applied to CD drug discovery, emphasizing the studies from the last five years.

Ligand and structure-based virtual screening applied to the SARS-CoV-2 main protease: an repurposing study.

The identification of drugs for the coronavirus disease-19 pandemic remains urgent. In this manner, drug repurposing is a suitable strategy, saving resources and time normally spent during regular drug discovery frameworks. Essential for viral replication, the main protease has been explored as a promising target for the drug discovery process.