Construction of tetravalent bispecific Tandab (CD3/BCMA)-secreting human umbilical cord mesenchymal stem cells and its efficiency in the treatment of multiple myeloma.

Background: Highly efficient targeted therapy is urgently needed for multiple myeloma (MM). Mesenchymal stem cells (MSCs) are an attractive candidate of cell-based, targeted therapy due to their inherent tumor tropism. However, there is still no MSCs-based tandem diabody for treating MM.

The novel prognostic analysis of AML based on ferroptosis and cuproptosis related genes.

Background: Acute myeloid leukemia (AML) is a hematological malignancy. The aim of this research was to develop a ferroptosis and cuproptosis related novel prognostic signature associated with AML.

Methods: The ferroptosis and cuproptosis related genes correlated with the prognosis of AML were identified by univariate Cox analysis.

Design and simulation of a secondary resource recycling system: A case study of lead-acid batteries.

The recycling of secondary resources is complicated as consumers, recyclers and governments are all involved in this process. In developing countries, compared to legal recyclers, illegal recyclers not only have cost advantages but also create serious pollution. Inappropriate management policies may cause disorder in the recycling market or inefficient fiscal management.

Platelet and peripheral white blood cell counts at diagnosis predict the response of adult immune thrombocytopenia to recombinant human interleukin-11: A retrospective, single-center, case-control study.

This study evaluated the effectiveness of recombinant human interleukin-11 (rhIL-11) in the treatment of immune thrombocytopenia (ITP) and determined whether clinical and laboratory findings predicted the treatment response.This retrospective, single-center, case-control study included 103 adult patients with ITP treated between July 2010 and April 2014 at Jiangxi Province People's Hospital. About 49 patients in the pred+IL group received prednisone (conventional dose) combined with an rhIL-11 regimen, and 54 patients in the pred alone group received prednisone (conventional dose) alone.

[FLK-1+ cells derived from mouse fetal liver could differentiate into endothelial cells and smooth muscle cells].

Objective: To characterize the differential and proliferative activities of FLK-1(+) cells derived from mouse fetal liver.

Method: The FLK-1(+) fraction were enriched from the fetal liver using immunomagnetic method and their differential and proliferative activities were examined in culture medium and in vivo via transplantation of FLK-1(+) cells into the inferior pole of the spleen of nine-week-old male C57 BL/6 mice after two-thirds hepatectomy.

Results: In response to growth factors, FLK-1(+) cells expressed typical lineage-specific markers for vascular endothelial cells, smooth muscle cells.