Publications by authors named "Wayne-Corentin Lambert"
Between March to December 2024, we observed a PEG-IFNα2a shortage in France for MPN patients. We identified and followed 90 patients from our center and observed 80% of difficulties obtaining the drug, and 61 patients among all (67.8%) did not receive their prescribed drug on time (impacted group).
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- MRD monitoring is essential for managing blood cancers, and while traditional methods use specific molecular targets, new research identifies additional fusion transcripts as potential markers for MRD.
- A study compared a focused RNA-seq method (FusionPlex) with a comprehensive RNA-seq approach (Advanta RNA-Seq XT) and found both methods had 100% agreement in detecting known fusions and good correlation in gene expression levels.
- In a trial with 126 patients, the targeted RNA-seq identified fusion transcripts in nearly half of the cases, leading to the development of specialized digital PCR tests for rare fusions, suggesting a potential shift in MRD evaluation techniques.
Article Synopsis
- Current risk scores for thrombotic events in myeloproliferative neoplasms (MPN) fail to differentiate between arterial and venous thrombosis, even though they have different causes and implications.
- A new score called ARTS, which considers factors like prior arterial thrombosis, age over 60, cardiovascular issues, and specific gene mutations, effectively stratifies patients into low- and high-risk groups for arterial thrombosis.
- Conversely, the VEnous Thrombosis Score (VETS), which only looks at prior venous thrombosis and JAK2 mutations, does not perform well, highlighting the need for better venous risk assessments that address its complexity.
Objective: Sex disparity is a major societal issue. The aim of this paper was to describe changes in the representation of women among speakers of the American Psychiatric Association (APA) annual meeting over 10 years, between 2009 and 2019 and to compare them to changes in the proportion of women among American psychiatrists.
Methods: Data were collected from the programs of the APA annual meetings of 2009 and 2019, and from the Association of American Medical Colleges.