Significant changes in preference of illicit drug use in a population of Hanoi, Vietnam-A 6-year wastewater study (2018-2023).

Background And Aim: Illicit drug use causes great harm and economical loss to society, yet there is limited understanding of its prevalence in the population in low-income countries like Vietnam where survey resources are scarce. In this study, we used wastewater analysis as a cost-effective monitoring tool to measure illicit drug use in a population of Hanoi, Vietnam, a low-income country in Southeast Asia.

Design, Setting And Participants: This is a longitudinal observational study.

Six years of alcohol consumption in Hanoi, Vietnam, by wastewater analysis: Assessing changes impacted by socio-economical factors.

Objectives: Alcohol consumption in Vietnam increased significantly over past decade alongside its economic development. However, in recent years, several alcohol control measures including a new drink-driving law and taxes as well as the COVID-19 pandemic have affected the consumption levels. This study aimed to monitor alcohol use trends in Hanoi over six consecutive years.

Correction: Comparison of excitation wavelengths in surface-enhanced Raman spectroscopy coupled to thin-layer chromatography for tadalafil and vardenafil detection as adulterants in herbal healthcare products.

Correction for 'Comparison of excitation wavelengths in surface-enhanced Raman spectroscopy coupled to thin-layer chromatography for tadalafil and vardenafil detection as adulterants in herbal healthcare products' by Dao Thi Cam Minh , , 2025, , 2867-2877, https://doi.org/10.1039/D5AY00219B.

Comparison of excitation wavelengths in surface-enhanced Raman spectroscopy coupled to thin-layer chromatography for tadalafil and vardenafil detection as adulterants in herbal healthcare products.

Phosphodiesterase-5 inhibitors (PDE5Is) are frequently adulterated into dietary supplements and herbal healthcare products, in which sildenafil, vardenafil and tadalafil are commonly found. In our previous study, a thin layer chromatography coupled to surface-enhanced Raman spectroscopy (TLC-SERS) method was developed for the detection of sildenafil in herbal products. In the current study, TLC-SERS was further explored for the detection of vardenafil and tadalafil in herbal products.

Optimization of meropenem continuous infusion based on Monte Carlo simulation integrating with degradation study.

Objective: Meropenem degradation poses a challenge to continuous infusion (CI) implementation. However, data about the impact of degradation on the probability of target attainment (PTA) of meropenem has been limited. This study evaluated the stability of meropenem brands and the consequence of in-bottle degradation on PTA in different environmental scenarios.

Assessing the impact of stricter drink driving policy on alcohol consumption in a population of Hanoi, Vietnam using wastewater analysis.

Introduction: On 1 January 2020, Vietnam introduced a new law with harsher fines and penalties for driving under the influence of alcohol. Reports of empty beer restaurants following this implementation suggested the new law has the potential to reduce population-level alcohol consumption. This pilot study aims to quantify short-term changes in alcohol consumption levels after the implementation of the new law and assess whether it could lead to a reduction in total alcohol consumption in the population.

Use of artificial sweeteners and caffeine in a population of Hanoi: An assessment by wastewater-based epidemiology.

Monitoring the consumption of artificial sweeteners in the population is essential to help public health authorities understand the level of sugar consumption. There is a gap in knowledge of patterns and levels of artificial sweetener consumption in Vietnam. Using wastewater-based epidemiology (WBE), this study aims to evaluate the use of artificial sweeteners in an urban population in Hanoi, Vietnam.

Optimizing Meropenem in Highly Resistant Klebsiella pneumoniae Environments: Population Pharmacokinetics and Dosing Simulations in Critically Ill Patients.

Critically ill patients are characterized by substantial pathophysiological changes that alter the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is a key antibiotic for multidrug-resistant Gram-negative bacilli, and such pathophysiological alterations can worsen treatment outcomes. This study aimed to determine the population PK of meropenem and to propose optimized dosing regimens for the treatment of multidrug-resistant Klebsiella pneumoniae in critically ill patients.

Prevalence of illicit drug consumption in a population of Hanoi: an estimation using wastewater-based epidemiology.

Illicit drug use is a serious issue in Vietnam, but information about their prevalence is scarce, mainly based on seizure data. Wastewater-based epidemiology (WBE) is an alternative tool for obtaining such information, especially when stigma related to drug use can hinder survey approaches. The study aimed to apply WBE to assess the prevalence of use of a range of illicit drugs in an urban population of Vietnam.

Peak shape enhancement using diethylamine in hydrophilic liquid interaction chromatography: Application in simultaneous determination of methionine and paracetamol.

Methionine (MET) is combined with paracetamol (PAR) in a pain relief soft capsule in order to prevent the haematologic damage of paracetamol. A hydrophillic liquid chromatographic (HILIC) method was developed for simultaneous determination of PAR and MET in the combined formulation. Various analytical conditions were investigated, and the final method was chosen using silica column (150 × 4,6 mm; 5 μm), mobile phase of acetonitrile - aqueous solution of 10 mM formic acid 5 mM diethylamine (60:40, v/v), UV detection at 254 nm for PAR and 210 nm for MET.

Occurrence of antibiotic residues and antibiotic-resistant bacteria in effluents of pharmaceutical manufacturers and other sources around Hanoi, Vietnam.

Pharmaceutical manufacturers in Vietnam are producing a wide variety of antibiotics for human and veterinary use. Consequently, the water discharged from those facilities can contain residues of antibiotics, which could have adverse impact on the environment. However, studies on the occurrence of antibiotics in the wastewater from pharmaceutical manufacturers in Vietnam are almost non-existent.

Antibiotics in the aquatic environment of Vietnam: Sources, concentrations, risk and control strategy.

The presence of antibiotics in the aquatic environment is a serious concern because it may lead to the emergence of antibiotic resistance, thus lowering the therapeutic effect of antibiotics. In Vietnam, the problem is aggravated by the irrational use of antibiotics in different sectors of agriculture and human health service. Moreover, the residues of antibiotics in the aquatic environment can be spread widely due to the lack of proper wastewater treatment systems.