Publications by authors named "Vitor Silvestre Teixeira"
Objectives: Current recommendations suggest treating eosinophilic granulomatosis with polyangiitis (EGPA) without severe manifestations with glucocorticoids (GCs) and EGPA with severe manifestations with GCs plus cyclophosphamide (CYC) regardless of poor-prognostic factors. However, GCs plus CYC and GCs alone have never been compared in EGPA without poor-prognosis factors assessed by the 1996 Five Factor Score (FFS). We aimed to compare the efficacy of GCs plus CYC vs GCs alone for the treatment of EGPA without poor-prognosis, including among patients with severe manifestations.
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- The study aimed to assess the effectiveness of combining glucocorticoids (GCs) with cyclophosphamide (CYC) for treating patients with poor-prognosis eosinophilic granulomatosis with polyangiitis (EGPA) compared to using GCs alone.
- Data from a European multicenter database were analyzed, involving 209 patients and focusing on relapse rates and other related outcomes over 12 to 24 months.
- Results indicated that adding CYC significantly reduced the risk of relapse and related complications compared to GCs alone, suggesting a beneficial role for CYC in the treatment of poor-prognosis EGPA.
Article Synopsis
- A task force of healthcare professionals created evidence-based recommendations for managing Raynaud's phenomenon and digital ulcers in patients with systemic sclerosis and other connective tissue diseases.
- The recommendations include 5 main principles and 13 specific suggestions, with a focus on coordinated team care and shared decision-making between patients and healthcare providers.
- Nifedipine is recommended as the first-line treatment, with other medications like sildenafil and tadalafil as second-line options, while non-drug interventions are advised but lack strong evidence.