Publications by authors named "Vincent T F Cheung"
Article Synopsis
- The study investigates immune checkpoint inhibitor (ICI)-colitis to understand its causes and similarities to idiopathic ulcerative colitis, aiming to find new treatment targets.
- Key findings reveal that activated CD8 T cells are predominant in ICI-colitis, and their activation is linked to the severity of the condition, differing from the patterns seen in ulcerative colitis.
- The research highlights that targeting these activated CD8 T cells with the JAK inhibitor tofacitinib shows promise as a treatment for ICI-colitis.
Article Synopsis
- Immune checkpoint blockers (ICBs) can activate CD8 T cells, leading to both positive anti-cancer effects and adverse immune-related events (irAEs), but their link to overall clinical outcomes is not well understood.* -
- A study examined the connection between irAE development and patient survival in metastatic melanoma by analyzing data from two groups of patients receiving different ICB treatments and assessing gene expression in CD8 T cells.* -
- Results showed that over half of the patients experienced early irAEs, which correlated with longer progression-free and overall survival, indicating that irAEs might reflect baseline immune activation and influence treatment outcomes.*
Immunotherapy induced enterocolitis and gastritis - What to do and when?
Best Pract Res Clin Gastroenterol
January 2021
Oncological treatment has been revolutionised by the advent of immune checkpoint inhibitors (ICPi), which block inhibitory immune pathways to enhance anti-tumour responses and improve survival. This mode of action is non-specific so can cause immune-related adverse events, of which diarrhoea and enterocolitis are amongst the most common. ICPi-enterocolitis frequently leads to cancer therapy interruption.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitors (ICI) improve survival but cause immune-related adverse events (irAE). We sought to determine if CTCAE classification, IBD biomarkers/endoscopic/histological scores correlate with irAE colitis outcomes.
Methods: A dual-centre retrospective study was performed on patients receiving ICI for melanoma, NSCLC or urothelial cancer from 2012 to 2018.
Background And Objectives: Radionuclide therapy has been used to treat patients with progressive/metastatic paragangliomas (PGLs) and phaeochromocytomas (PCCs). The aim of the present study is to retrospectively compare the therapeutic outcomes of these modalities in patients with progressive/metastatic PCCs and PGLs.
Methods: Patients with progressive/metastatic PGLs and PCCs that were subjected to radionuclide treatment in our department were retrieved from our department's database for the period 1998-2013.
A guide to midgut neuroendocrine tumours (NETs) and carcinoid syndrome.
Frontline Gastroenterol
October 2015
Patients with midgut neuroendocrine tumours or carcinoid syndrome often face a delayed diagnosis. This article aims to highlight the different ways in which patients with midgut neuroendocrine tumours (NETs) present, the diagnostic approach to them, the current methods of management available and future considerations.
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