Publications by authors named "Viktoria Flore"
Cellular interactions are of fundamental importance, orchestrating organismal development, tissue homeostasis and immunity. Recently, powerful methods that use single-cell genomic technologies to dissect physically interacting cells have been developed. However, these approaches are characterized by low cellular throughput, long processing times and high costs and are typically restricted to predefined cell types.
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- The influenza A virus (IAV) genome is segmented and needs a coordinated packaging process into virions, which relies on interactions between viral RNA packaging signals and the viral nucleoprotein (NP).
- Researchers investigated how mutations in packaging signals and specific amino acid changes in the NP affected this packaging process, focusing on lysine residues that can change charge states in host cells.
- The findings suggest that the charge state of these lysines impacts the efficiency of vRNA packaging, indicating that lysine acetylation plays a significant role in coordinating the incorporation of RNA segments into the viral structure.