Publications by authors named "Victoria Ghesquier"
Macrophages are widely distributed innate immune cells that play an indispensable role in a variety of physiologic and pathologic processes, including organ development, host defense, acute and chronic inflammation, solid and hematopoietic cancers. Beyond their inextricable role as conveyors of programmed cell death, we have previously highlighted that caspases exert non-apoptotic functions, especially during the differentiation of monocyte-derived cells in response to CSF-1. Here, we found that non-canonic cleavages of caspases, reflecting their activation, are maintained during IL-4-induced monocyte-derived macrophages polarization.
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- AMPK is a key regulator of energy balance in cells, influencing growth and survival, and activation of AMPK has shown potential anti-cancer effects, particularly in acute myeloid leukemia (AML).
- The study reveals that the AMPK activator GSK621 triggers the unfolded protein response (UPR) in AML cells, causing changes in energy metabolism that promote cell death.
- Combining GSK621 with the Bcl-2 inhibitor venetoclax enhances the effectiveness of treatment, suggesting that AMPK activation could be a promising strategy for AML therapy through reshaping mitochondrial processes.