Publications by authors named "Victor Heurtier"
Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contribute to cell fate restriction as differentiation proceeds. Accordingly, in undifferentiated and pluripotent mouse Embryonic Stem (ES) cells the global levels of H3K9 methylation are rather low and increase only upon differentiation. How global H3K9 methylation levels are coupled with the loss of pluripotency remains largely unknown.
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- * The study reveals that Nanog enhances embryonic stem cell self-renewal through various mechanisms, especially in the presence of LIF, where it increases chromatin accessibility and helps bind pluripotency factors to enhancers.
- * In the absence of LIF, Nanog inhibits differentiation by maintaining a repressive histone mark (H3K27me3) at developmental regulators, notably repressing the gene Otx2, which is crucial for this process.
Nutrition during the perinatal period programs body growth. Growth hormone (GH) secretion from the pituitary regulates body growth and is controlled by Growth Hormone Releasing Hormone (GHRH) neurons located in the arcuate nucleus of the hypothalamus. We observed that dietary restriction during the early postnatal period (i.
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