Time-to-event analysis of the long-term outcome in trials comparing transcatheter and surgical aortic valve implantation: A meta-analysis.

Objective: Indications for TAVI have been widened, although long-term device efficacy is still unclear. We aimed to compare the effectiveness of transcatheter aortic valve implantation (TAVI) vs. surgical aortic valve replacement (SAVR) on a composite of death from any cause or stroke at 5-year follow-up according to risk profiles.

Long-term outcomes of patients undergoing multiarterial grafting in coronary artery bypass grafting: Insights from a Latin American national cohort.

Background: Coronary artery bypass grafting (CABG) remains a cornerstone treatment for multivessel coronary artery disease. While single-artery revascularization has been the standard, the use of multiarterial grafting (MAG) is associated with superior long-term outcomes. However, its adoption is limited by technical challenges and potential complications.

Comparative evaluation of mechanical and biological prostheses in patients with aortic stenosis.

Objectives: The commonly accepted aortic valve prostheses have been either mechanical or biological. Each type has its advantages and disadvantages, with age being the most widely accepted variable to determine the best option. There is, however, a range between 60 and 70 years where an individualized approach is required.

Long-term mortality after coronary surgery in women patients depend on diabetes and age.

Objectives: There is general consensus of the higher short-term risk in women after coronary artery bypass grafts (CABG), nonetheless, long-term survival is a matter of debate. We aimed to compare in a national database with over 10 years of follow-up long-term survival in women versus men and its interaction with diabetes and age.

Methods: This is a national retrospective cohort study from Uruguay.

Intra-operative and post-operative management of conduits for coronary artery bypass grafting: a clinical consensus statement of the European Society of Cardiology Working Group on Cardiovascular Surgery and the European Association for Cardio-Thoracic Surgery Coronary Task Force.

The structural and functional integrity of conduits used for coronary artery bypass grafting is critical for graft patency. Disruption of endothelial integrity and endothelial dysfunction are incurred during conduit harvesting subsequent to mechanical or thermal injury and during conduit storage prior to grafting, leading to acute thrombosis and early graft failure. Late graft failure, in particular that of vein grafts, is precipitated by progressive atherogenesis.

Medium-term survival of patients with mechanical and biological aortic prosthesis at the 6th decade of life.

Objective: The best aortic prosthesis type in 60-70 year old patients is not established. Our aim was to evaluate the survival in a National cohort of patients between 60-70 years old who required surgical aortic valve replacement for aortic stenosis (SAVR) with either a mechanical (MP) or bioprosthesis (BP) valve.

Methods: This is a retrospective study using national data from the Ministry of Health.

Warfarin use is associated with higher aortic bioprosthetic 18F-fluoride PET uptake.

Background: Prevalence of bioprosthetic valve degeneration (BVD) is rising as the use of bioprosthetic aortic valves increases. Detecting early signs of BVD remains a challenge, with conventional imaging methods often failing to identify early deterioration stages. 18F-fuoride positron emission tomography (PET-CT) is an emerging technique that offers promising prospects to detect subclinical BVD.

Early anticoagulation after aortic valve replacement with porcine bioprosthesis randomized control trial(ANTIPRO). 3 years follow-up.

Background: Most evidence for anticoagulation in aortic bioprosthesis is centered on embolic events, bleeding and re-intervention risk. The effect of anticoagulation on hemodynamics has not been previously assessed. Our hypothesis was that patients with anticoagulation (AC) early after aortic valve replacement (AVR) with porcine bioprosthesis have better hemodynamics at 3 years of follow-up.

Composite end points and competing risks analysis.

Composite end points are common primary outcomes in clinical trials. Their main benefit of utilizing a composite outcome is increasing the number of primary outcome events, meaning fewer participants are required to deliver an adequately powered trial. By combining multiple important end points in the primary outcome rather than having to select only 1, composite end points potentially make clinically meaningful benefits easier to detect and avoid ranking outcomes hierarchically.

The ISCHEMIA trial revisited: setting the record straight on the benefits of coronary bypass surgery and the misinterpretation of a landmark trial.

Objectives: The ISCHEMIA trial is a landmark study that has been the subject of heated debate within the cardiovascular community. In this analysis of the ISCHEMIA trial, we aim to set the record straight on the benefits of coronary artery bypass grafting (CABG) and the misinterpretation of this landmark trial. We sought to clarify and reorient this misinterpretation.