Publications by authors named "Venetia Owenson"
Article Synopsis
- The Phase III CAPItello-291 trial showed that combining capivasertib (an AKT inhibitor) and fulvestrant (a SERD) improved progression-free survival for HR+ breast cancer patients after aromatase inhibitors, but prior treatment with CDK4/6 inhibitors may lessen the effectiveness of future endocrine therapies.
- Researchers examined how CDK4/6 inhibitors affect the function of estrogen receptor-positive (ER+) breast cancer cells and their responses to fulvestrant and capivasertib, finding varied gene expression and signaling alterations in resistant cell lines.
- Despite reduced efficacy and changes in cellular signaling in both RB+ and RB- resistant models, the combination therapy was still effective in reducing cell cycle activity
The putative cache (Ca channel and chemotaxis receptor) domain containing 1 (CACHD1) protein has predicted structural similarities to members of the α2δ voltage-gated Ca channel auxiliary subunit family. CACHD1 mRNA and protein were highly expressed in the male mammalian CNS, in particular in the thalamus, hippocampus, and cerebellum, with a broadly similar tissue distribution to Ca3 subunits, in particular Ca3.1.
View Article and Find Full Text PDF