Publications by authors named "Veda K Kulkarni"
Frequency and Genotype-Dependence of intrinsic chronotropic insufficiency among patients with congenital long QT syndrome.
J Cardiovasc Electrophysiol
January 2025
Article Synopsis
- Long QT syndrome (LQTS) is a heart condition associated with prolonged QT intervals, which can lead to serious events like arrhythmias and sudden cardiac arrest. The study aims to explore if patients with untreated LQTS experience chronotropic insufficiency (CI), a condition where the heart cannot sufficiently increase its rate in response to exercise.
- A retrospective analysis was conducted on 463 patients with different LQTS genotypes (LQT1, LQT2, LQT3), focusing on those who were not on beta blockers; about 51% of these patients exhibited CI, with LQT1 patients showing the highest prevalence.
- The findings suggest that while patients with LQTS, especially LQT1, have
Background: Long QT syndrome (LQTS) is a sudden death predisposing condition characterized by ECG-derived prolongation of the QT interval. Previous studies have demonstrated that the supine-stand test may aid in the diagnosis of LQTS as patients fail to shorten their QT interval in response to standing up. The aim of this study was to evaluate the diagnostic accuracy of ECG data derived from standard protocol, clinically performed treadmill exercise stress tests (TESTs) in their ability to mimic the formal supine-stand test.
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