Publications by authors named "Valeria Trapani"
Collagen VI (COL6) is an extracellular matrix protein exerting multiple functions in different tissues. In humans, mutations of COL6 genes cause rare inherited congenital disorders, primarily affecting skeletal muscles and collectively known as COL6-related myopathies, for which no cure is available yet. In order to get insights into the pathogenic mechanisms underlying COL6-related diseases, diverse animal models were produced.
View Article and Find Full Text PDFCollagen VI (ColVI) is an extracellular matrix (ECM) protein involved in a range of physiological and pathological conditions. Zebrafish (Danio rerio) is a powerful model organism for studying vertebrate development and for in vivo analysis of tissue patterning. Here, we performed a thorough characterization of ColVI gene and protein expression in zebrafish during development and adult life.
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- The notochord is an important structure in chordate animals, providing mechanical support and signaling during embryo development.
- In vertebrates, it helps pattern surrounding tissues and consists of vacuolated cells with a protective extracellular matrix (ECM) that must be organized correctly for proper development.
- Recent studies have explored how different ECM components influence notochord development and signals, and they also connect ECM processes to the formation of chordoma, a type of cancer linked to notochord remnants.
The notochord is an embryonic midline structure common to all members of the phylum Chordata, providing both mechanical and signaling cues to the developing embryo. In vertebrates, the notochord arises from the dorsal organizer and it is critical for proper vertebrate development. This evolutionary conserved structure located at the developing midline defines the primitive axis of embryos and represents the structural element essential for locomotion.
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- The notochord is a crucial structure in developing vertebrates, providing mechanical and signaling support during embryo formation.
- Researchers discovered that the glycoprotein Emilin3 is vital for the notochord sheath in zebrafish, as knockdown of Emilin3 disrupts sheath development.
- Emilin3 also influences Hedgehog (Hh) signaling in the notochord, affecting embryo patterning by interacting with the factor Scube2, thus highlighting how structure and function in the notochord are interconnected.