POSTTRAUMATIC SUBUNGUAL ACRAL NODULAR MELANOMA WITH BONE INFILTRATION TREATED VIA AMPUTATION OF THE DISTAL AND MIDDLE PHALANX: DESCRIPTION OF A CASE AND UPDATE ON THE TOPIC.

Acral lentiginous melanoma (ALM) is a rare type of cutaneous malignant melanoma, predominantly affecting the acral sites and subungual regions of the upper and lower extremities. Unlike other melanoma types, UV exposure is not considered as significant etiological factor. Instead, mechanical stress, particularly traumatic injury, is recognized as a potential contributor to ALM development, especially in weight-bearing areas such as the sole.

"DERMATOLOGIC SURGERY (GNP) GROUND AND POUND"- EXTENDABLE PLASTIC SURGERY WITH PRIMARY WOUND CLOSURE AS OPTIMAL TREATMENT OPTION FOR MIDDLE-SIZED CONGENITAL DYSPLASTIC NEVUS OF THE BACK OF AN 8-YEAR-OLD BOY.

Surgical treatment of congenital melanocytic nevi is a serious problem for the relatives and "small patients" as well as for dermatosurgeons. The responsibility of the medical team is enormous, analogous to the expectations of the parents themselves. The aggressive dermatosurgical approach is usually short-lasting but effective and depends on the size and localization of the nevus as well as the experience of the dermatosurgeon.

NITROSAMINES IN METFORMIN AND HYDROCHLOROTHIAZIDE: "HUMAN SAFE PHOTOCARCINOGENS" WITHIN THE POLYPHARMACY AS GENERATOR FOR PHOTOTOXICITY/ PHOTOCARCINOGENICITY AND THE SUBSEQUENT DEVELOPMENT OF MULTIPLE KERATINOCYTE CARCINOMAS. DOUBLE HATCHET FLAP AS OPTIMAL AND NECESSARY DERMATOSURGICAL DECISION IN TWO NEW PATIENTS.

The issues that have been identified to date as potentially pivotal in relation to skin cancer in general, but also keratinocytic cancer in particular, mainly concern the permanent potentiation of concepts such as phototoxicity and hence its subsequent photocarcinogenicity over time. Studies by scientific teams dating back more than 50 years have defined the phototoxicity of nitrosamines as a rather non-specific property, regardless of whether the last mentioned have a carcinogenic effect or not. Recently or in 11/ 2024, hydrochlorothiazide was officially declared by the IARC/ International agency on cancer research as carcinogenic to humans due to its phototoxicity.

[Microsporum canis infection from a cat : A source of tinea capitis and dermatophytosis in an entire family].

Tinea capitis is a common fungal infection of the scalp predominantly affecting children. It is often misdiagnosed due to its clinical resemblance to other dermatological conditions such as psoriasis and seborrheic dermatitis. This case report presents a 4-year-old boy who was initially misdiagnosed and treated for psoriasis but later correctly diagnosed with tinea capitis caused by Microsporum canis.

POLYPHARMACY, DRUG RELATED NITROSAMINE CONTAMINATION (BISOPROLOL/PROPAFENONE) AND THE LINK TO LICHEN PLANUS/SUBSEQUENT DEVELOPMENT OF KERATINOCYTE AND MUCOSAL CANCER/ORAL LEUKOPLAKIA: PRESENTATION OF THE FIRST CASE AND UPDATE ON THE NEW PATHOGENETIC VISION.

The association between drug-induced lichen planus - whether oral/mucosal or solely cutaneous - involves a diverse range of drugs, including ACE inhibitors, diuretics, and beta blockers, as well as quinidine, NSAIDs, hydroxychloroquine, antiretroviral medications for HIV, penicillamine, TNF inhibitors, and certain medications for type 2 diabetes. The natural course of lichen planus has been also linked in certain cases to the development of squamous cell carcinoma, affecting both mucous membranes and skin, as extensively documented in the literature. However, little attention has been given to the fact that many of the medications associated with lichen planus - such as ACE inhibitors, diuretics, and beta blockers - are listed by the FDA as contaminated with carcinogenic and mutagenic nitrosamines.