Publications by authors named "Utku Deniz"
Global fruit production suffers from pre- and post-harvest losses, part of which are related to metal deficiencies. Despite fruits being one of the most widely consumed plant parts, the spatial distribution of metals and their possible physiological impact remained largely unexplored. In this study, we searched for conserved metal accumulation sites in fruits of various crops and investigated their physiological function.
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- - Hybrid seed inviability (HSI) plays a crucial role in reproductive isolation, impacting speciation by varying in strength among diploid species and potentially influencing ploidy-variable species as well.
- - The study examined HSI variation within a diploid-autotetraploid species using data from 12 population pairs across three different contact zones, focusing on the effects of crossing direction, ploidy differences, and spatial arrangement on reproductive barriers.
- - Results revealed significant parent-of-origin effects on endosperm development and hybrid performance, indicating that these variations contribute to interploidy reproductive isolation and the overall fitness of the species, highlighting HSI as a key factor regardless of evolutionary history.
Article Synopsis
- A decrease in sphingosine 1-phosphate (S1P) levels is linked to the migration of harmful T cells in conditions like multiple sclerosis (MS) and Alzheimer's disease (AD), highlighting a potential therapeutic target.
- An integrated strategy involving virtual screening, molecular docking, and dynamic simulations led to the discovery of 10,000 potential inhibitors of the enzyme sphingosine 1-phosphate lyase (S1PL), which breaks down S1P.
- Ultimately, 15 candidate compounds were identified for further development as S1PL inhibitors, providing a pathway for future medicinal chemistry aimed at treating diseases driven by pathogenic T cells.
Identification of potential Tpx inhibitors against pathogen-host interactions.
Comput Biol Chem
October 2015
Yersinia organisms cause many infectious diseases by invading human cells and delivering their virulence factors via the type three secretion system (T3SS). One alternative strategy in the fight against these pathogenic organisms is to interfere with their T3SS. Previous studies demonstrated that thiol peroxidase, Tpx is functional in the assembly of T3SS and its inhibition by salicylidene acylhydrazides prevents the secretion of pathogenic effectors.
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