Systemic Lupus Erythematosus (SLE) is an autoimmune disorder known to increase the risk of lymphomas, typically after prolonged immunosuppressive therapy. We report a rare case of a 45-year-old woman who presented with fever, polyarthritis, and anasarca, and was concurrently diagnosed with lupus nephritis and marginal zone lymphoma without prior immunosuppression. Initial evaluation revealed hematologic abnormalities, renal involvement, and axillary lymphadenopathy.
View Article and Find Full Text PDFThe simultaneous occurrence of vasculitic glomerulonephritis and membranous nephropathy is unusual. We report two cases that presented to our outpatient department with rapidly progressive renal failure. On evaluation, in one patient, anti-myeloperoxidase (MPO) titers were high, and renal biopsy was suggestive of concurrent necrotizing and diffuse crescentic anti-MPO anti-neutrophil cytoplasmic antigen-associated glomerulonephritis with the circumferential cellular crescent formation and membranous glomerulopathy.
View Article and Find Full Text PDFUnlabelled: Dual anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) characterized by the presence of both anti-proteinase-3 (PR3-ANCA) and anti-myeloperoxidase (MPO-ANCA) antibodies is a rare clinical entity. Only few cases have been reported previously, most of which were associated with infections, drugs, autoimmune diseases and malignancies. Herein, we describe a young woman who presented with rapidly progressive glomerulonephritis with hypocomplementemia and markedly elevated anti-PR3 and anti-MPO titres.
View Article and Find Full Text PDFIntroduction: Globally, stroke is one of the leading causes of death and disability-adjusted life-years (DALYs). The red cell distribution width (RDW) is a readily available and inexpensive test which is done routinely as a part of complete blood count in these patients.
Objective: In this study, we tried to correlate the RDW with severity of acute ischemic stroke (AIS).