Mineralized chitin nanocrystals enhance osteoinductive ability of chitosan 3D porous biohybrid scaffolds for bone tissue regeneration.

The loss of alveolar bone due to periodontitis has high worldwide prevalence, and Tissue Engineering (TE) emerges as an alternative to replace autologous bone grafting. Herein, TE fundamentals were applied to mimic bone extracellular matrix (ECM) and cells microenvironment. First, biomimetic hydroxyapatite-based mineralized chitin nanocrystals (MCHNC) from both alpha or beta isoforms were synthesized, showing excellent in vitro biocompatibility and osteoinductive properties over human adipose-derived mesenchymal stem cells (hASCs) osteogenic differentiation.

Trilayered nanocellulose-based patches loaded with acyclovir and hyaluronic acid for the treatment of herpetic lesions.

This study focuses on the preparation of layered bacterial nanocellulose (BNC) patches for drug delivery and wound healing in the context of herpes labialis. Nanostructured patches were prepared by selective aqueous diffusion of acyclovir (ACV, antiviral drug), hyaluronic acid (HA, skin healing promoter), and glycerol (GLY, plasticizer and humectant) in the BNC network, followed by assembly into trilayered patches with ACV on the central layer of the patch (ACV) or divided between two layers (ACV), to modulate drug release. Both patches showed good layers' adhesion and thermal stability (125 °C), UV barrier properties, good static (Young's modulus up to 0.