Vaccine fatigue and influenza vaccination trends across Pre-, Peri-, and Post-COVID-19 periods in the United States using epic's cosmos database.

Introduction: Influenza vaccination is a critical public health measure, especially amidst the challenges of the COVID-19 pandemic. This study uses Epic's Cosmos database to analyze influenza vaccination trends across demographic groups in the United States, examining the effects of the COVID-19 pandemic and "vaccine fatigue" on influenza vaccination rates.

Methods: This retrospective cross-sectional study analyzes influenza vaccination rates pre- (1 May 2018-31 May 2019), peri- (1 May 2020-31 May 2021), and post-COVID-19 (1 May 2023-31 May 2024).