The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury.

Background: There is limited data on applying urinary biomarkers for prediction of kidney outcomes in pediatric acute kidney injury (AKI).

Methods: We prospectively measured urinary neutrophil gelatinase-associated lipocalin (NGAL), tissue metalloproteinases-2 (TIMP-2), insulin-like growth factor-binding protein 7 (IGFBP-7) and C-C motif chemokine ligand 14 (CCL14), alongside serum kidney function test in critically ill children with AKI admitted to the pediatric intensive care unit. The primary outcomes included persistent AKI (lasting for ≥ 72 h) and prolonged AKI (lasting for ≥ 7 days).