Publications by authors named "Treasa B O'Hagan"
Asymmetric loading of TnsE regulates Tn7 targeting of DNA replication structures.
Nucleic Acids Res
June 2025
Tn7 transposable elements are known for their sophisticated target-site selection mechanisms. For the prototypical Tn7 element, dedicated transposon-encoded proteins direct insertions to either a conserved site in the chromosome or replicating DNA structures in conjugal plasmids, ensuring the vertical and horizontal spread of the element. While the pathway targeting the attTn7 site in the bacterial chromosome has been extensively studied, the pathway targeting DNA replication structures remains poorly understood.
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- * Current treatment for CD is difficult due to a lack of effective and safe drugs, prompting research into the enzyme TcAkt as a potential drug target.
- * By using advanced techniques like Nuclear Magnetic Resonance and Molecular Dynamics simulations, the study identifies how TcAkt interacts with specific ligands and proposes a mechanism for its activation, showing that existing human inhibitors can potentially target TcAkt for drug development.