Comparative outcomes of unilateral biportal endoscopic lumbar intervertebral discectomy with and without annulus fibrosus suture in lumbar disc herniation: a retrospective analysis.

Background: Advancements in minimally invasive spine surgery have markedly enhanced patient outcomes in the management of lumbar intervertebral disc herniation and degenerative disorders. The Unilateral Biportal Endoscopic Interlaminar Lumbar Intervertebral Discectomy and spinal nerve decompression are prominent of these methods. This method is based on the principles established by several endoscopic spine techniques, which are lauded for their limited invasiveness, less trauma, and expedited recovery periods in contrast to conventional open operations.

Long-Term Efficacy and Surgical Outcomes of Sural Neurovascular Flap Applications in Distal Lower Limb Wound Reconstruction: A Single-Center Retrospective Study of Patients Treated in Jingzhou City From 2012 to 2018.

Background And Aim: The sural neurovascular flap has been effectively used to reconstruct complex tibial and soft tissue defects caused by severe trauma, promoting successful wound repair and healing. Proactive management is essential in minimizing postoperative complications and achieving optimal outcomes. This study evaluates the efficacy and long-term outcomes of sural neurovascular flap applications in distal lower limb wound reconstruction.

ESR1-dependent suppression of LCN2 transcription reverses autophagy-linked ferroptosis and enhances sorafenib sensitivity in hepatocellular carcinoma.

Sorafenib resistance is a significant hurdle in the treatment landscape of hepatocellular carcinoma (HCC). Lipocalin 2 (LCN2), a secretory glycoprotein that transports lipophilic molecules across cell membranes, is thought to affect the s therapeutic efficacy of sorafenib. Despite its importance, the detailed regulatory pathways involving LCN2 are still being deciphered.