Mechanism of shear stress-induced ATP release in ventricular myocytes: roles of pannexin and mitochondria.

Shear stress induces atrial Ca waves via connexin43 (Cx43)-mediated ATP release. Here, we examined whether ventricular myocytes release ATP under shear stress and the underlying and regulatory mechanisms. A bioluminescence assay and the "sniffer patch" were used to measure ATP release from multiple and single murine ventricular myocytes, respectively, in combination with laminar flow or micro-puffing.

An unusual case of spinal cord compression secondary to iliopsoas cavernous hemangioma: A case report and literature review.

Rationale: We report on a 16-year-old woman who had a history of a vascular malformation involving the left iliopsoas muscle and underwent multiple sclerotherapy sessions over the preceding 5 years without clinical improvement.

Patient Concerns: Ten days before admission, the patient experienced the acute onset of paraparesis. Computed tomography and magnetic resonance imaging revealed a large vascular malformation, measured 90 × 100 × 100 mm, situated at the T12 to L4 vertebral levels within the left iliopsoas muscle, exerted significant compression on the conus medullaris and cauda equina.

Improved detection and localization of insulinoma using small field-of-view diffusion-weighted MRI: A case report.

Insulinoma is a rare but challenging-to-diagnose pancreatic neuroendocrine tumor, often presenting with recurrent spontaneous hypoglycemia. Surgical resection remains the definitive treatment; however, accurate preoperative localization is critical for optimizing surgical outcomes and avoiding unnecessary extensive pancreatic resection. We report a case of a 57-year-old female with recurrent hypoglycemia, whose lesion was undetectable using conventional ultrasound, computed tomography (CT), and standard magnetic resonance imaging (MRI).

Laparoscopic cholecystectomy induce tension pneumocephalus in a patient with ventriculoperitoneal shunt: A case report and literature review.

Introduction And Patient Concerns: We report on a 45-year-old woman who has a ventriculoperitoneal shunt (VPS), experienced drowsy mental status, with hypesthesia and hemiplegia on the left side. Ten days ago she underwent laparoscopic cholecystectomy (LC). Computed tomography revealed tension pneumocephalus, with severe compression on the right side of the brain.

Radical resection of trigeminal schwannoma at the cerebellopontine angle with support of the digital robotic exoscope Synaptive Modus V system: A case report and literature review.

Rationale And Patient Concerns: We report on a 67-year-old woman who experienced drowsy mental status, facial numbness, and hearing loss on the right side; the symptom gradually worsened over the last 4 years. Brain magnetic resonance imaging revealed a 4.8 × 1.

Insights from Drosophila melanogaster model of Alzheimer's disease.

Alzheimer's disease (AD) is a common chronic neurodegenerative disease that mainly affects the medial temporal lobe and associated neocortical structures. The disease process involves two abnormal structures, plaques and tangles, which damage and destroy nerve cells. Tangles are twisted fibers of tau protein that build up inside cells.