Publications by authors named "Thomas Steimle"
TAL1 is one of the most frequently dysregulated oncogenes in T-cell Acute Lymphoblastic Leukaemia (T-ALL). However, the precise frequency and prognostic impact associated with its dysregulation remains unclear and is confounded by TAL1's diverse dysregulation mechanisms. TAL1 dysregulation is detected by TAL1 transcript quantification, though this technique may be subject to interference by TAL1 transcripts deriving from residual haematological cells that physiologically express high levels of the gene.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates genomic imbalances in 317 newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) patients using single nucleotide polymorphism (SNP) array analysis, focusing on clinical features and outcomes.* -
- The majority of patients (approximately 96%) showed at least one genomic imbalance, with del(9)(p21) being the most common, followed by other significant deletions involving various chromosomal regions.* -
- The research identified specific genomic patterns related to age and subclassifications of T-ALL, and established a threshold of 15 imbalances for defining high- and low-risk relapse groups, highlighting the importance of genomic complexity in predicting survival outcomes.*
The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not been recurrently reported in clinical patient lymphoma/leukemia samples. Using a specifically designed NGS-capture pipeline, we here demonstrated the reintegration of T-cell receptor excision circles (TRECs) in 20/1533 (1.
View Article and Find Full Text PDFT-cell acute lymphoblastic leukemias (T-ALL) represent 15% of pediatric and 25% of adult ALL. Since they have a particularly poor outcome in relapsed/refractory cases, identifying prognosis factors at diagnosis is crucial to adapting treatment for high-risk patients. Unlike acute myeloid leukemia and BCP ALL, chromosomal rearrangements leading to chimeric fusion-proteins with strong prognosis impact are sparsely reported in T-ALL.
View Article and Find Full Text PDFT-cell acute lymphoblastic leukemia (T-ALL) represents the malignant expansion of immature T cells blocked in their differentiation. T-ALL is still associated with a poor prognosis, mainly related to occurrence of relapse or refractory disease. A critical medical need therefore exists for new therapies to improve the disease prognosis.
View Article and Find Full Text PDF