Publications by authors named "Thomas D Kimble"
Introduction: Preeclampsia (PE) is a complex multisystem disorder of pregnancy associated with abnormal placentation, vascular anomalies, and systemic inflammation and hypertension. Previous research assessing inflammatory triggers of the condition used plasma, amniotic fluid, or explant samples. Studies using placental tissue from either vaginal or cesarean deliveries are confined to semiquantitative analysis using subjective scoring methods and generally involve a small sample size.
View Article and Find Full Text PDFObjective: This study aimed to evaluate the acceptability of the Woman's Condom (WC) over 6 months (183 days) and ≥6 menstrual cycles in a US-based multicenter open-label phase III contraceptive efficacy trial.
Study Design: We assessed acceptability via written questionnaire at visit 2 (after the third cycle) and visit 3 (after the sixth cycle or >183 days, or upon early discontinuation). Key domains included ease of use, comfort/lubrication, sexual satisfaction, male partner satisfaction and confidence in pregnancy and sexually transmitted infection (STI) prevention.
Background: Vulvovaginal atrophy (VVA) is characterized by vaginal/vulvar dryness, irritation, dyspareunia, or dysuria. The objective of this study was to examine the efficacy and safety of a very low-dose estradiol vaginal cream (0.003%) applied twice per week in postmenopausal women with VVA-related vaginal dryness.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness of DNA and protein-based biomarkers from used vaginal gel applicators compared to standard visual inspection methods in determining their usage.
- DNA and protein biomarkers showed high sensitivity (98.3%) and specificity (100%) for confirming vaginal insertion, while visual inspection methods (VIRA and UVL) demonstrated significantly lower accuracy.
- These findings suggest that DNA and protein biomarkers provide a more reliable way to confirm product use, even after storage for about 30 days.
Background: We evaluated apoptosis in human endometrial endothelial cells (HEECs) incubated with progesterone, levonorgestrel (LNG) and medroxyprogesterone acetate (MPA).
Study Design: HEECs were cultured to near confluence, and the progestogens were added.
Setting: Academic Department of Obstetrics and Gynecology.
Objective: The objective of this study was to evaluate basal anti-Müllerian hormone as a marker for ovarian responsiveness to fertility treatment.
Study Design: Frozen basal menstrual cycle day 3 serum samples were evaluated retrospectively for anti-Müllerian hormone, inhibin B, and follicle-stimulating hormone levels in 123 in vitro fertilization cycles (93 patients) and compared with in vitro fertilization records.
Results: Anti-Müllerian hormone values correlated the best with the number of retrieved oocytes (r = 0.