Identifying distinct clusters of ICU survivors by integrating demographic, pre-admission quality of life, and clinical data: a large prospective cohort study.

Purpose: ICU patients differ in pre-ICU health status, comorbidities, and diagnosis, forming a heterogeneous population with diverse long-term outcomes. This study explored whether clustering ICU patients by demographic, pre-admission quality of life, and clinical data, rather than by diagnosis, could identify subgroups that are more informative for patient-centered outcomes post-ICU.

Methods: Data from the MONITOR-IC prospective cohort study were used.

Redefinition of Myocardial Infarction After Cardiac Surgery: A two-centre Clinical Evaluation of the Proposed European Association for Cardio-thoracic Surgery Algorithm for the Diagnosis of Perioperative Myocardial Injury and Infarction.

Objective: This study evaluated the clinical applicability and relevance of the European Association for Cardio-thoracic Surgery (EACTS) algorithm for the diagnosis of perioperative myocardial injury and myocardial infarction (PMI) after cardiac surgery, compared to the Fourth Universal Definition of Myocardial Infarction (4UD).

Design: This was a prospective two-centre cohort study in adults undergoing a range of elective and urgent cardiac surgeries. PMI and myocardial injury were diagnosed using both the EACTS algorithm and the 4UD.

Does postoperative plasma IL-6 improve early prediction of infection after pulmonary cancer surgery? A two-centre prospective study.

Introduction: Postoperative hyperinflammation increases infection risk. We hypothesized that interleukin-6 (IL-6) is an early predictor of infection after pulmonary cancer surgery.

Methods: A two-centre prospective cohort study, including consecutive elective pulmonary cancer surgery patients.

Improving Prediction of Postoperative Atrial Fibrillation After Cardiac Surgery Using Multiple Pathophysiological Biomarkers: A Prospective Double-Centre Study.

Postoperative atrial fibrillation (POAF) is a common and serious complication after cardiac surgery. Existing clinical prediction models show limited discriminative ability. We hypothesize that incorporating biomarkers that reflect key pathophysiological pathways of POAF can enhance preoperative risk stratification.

Association between pre-operative borderline anaemia in women and outcome after coronary artery bypass grafting: data from the Netherlands Heart Registration.

Background: Haemoglobin concentration thresholds differ between men and women, with borderline anaemia (haemoglobin ≥ 12.1 and < 13.1 g dl -1 ) considered normal in women.

The Effects of Dexamethasone in Cardiac Surgery: A Registry-Based, Real-World Data Analysis of Clinical Outcomes From the Netherlands Heart Registration.

Background: In cardiac surgery, modulating the inflammatory response with prophylactic steroids may reduce morbidity and mortality. We aimed to evaluate the association of dexamethasone use with clinical outcomes and its variation in clinical practice in a real-world setting.

Methods: This retrospective, population-based study evaluated data of elective and urgent to on-pump cardiac surgery patients from the Netherlands Heart Registration between 2013 and 2021.

Neutrophil phenotypes quantify tissue damage caused by major surgery.

Introduction: Major surgery triggers an innate immune response that can become excessive, leading to immune suppression and an increased risk of infection. Neutrophils are crucial in this response, and changes in their phenotype are associated with the severity of the innate immune response. This study examines the effect of major surgery on neutrophil phenotypes using fully automated flow cytometry.

Associations Between Social Economic Determinants and Long-Term Outcomes of Critically Ill Patients.

Objective: Differences in socioeconomic status (SES) may influence long-term physical, psychological, and cognitive health outcomes of ICU survivors. However, the relationship between SES and these three long-term health outcomes is rarely studied. The aim of this study was to investigate associations between SES and the occurrence of long-term outcomes 1-year post-ICU.

Associations Between Physical, Cognitive, and Mental Health Domains of Post-Intensive Care Syndrome and Quality of Life: A Longitudinal Multicenter Cohort Study.

Objectives: To explore associations between the physical, cognitive, and mental post-intensive care syndrome (PICS) health domains with changes in health-related quality of life (HRQoL) following ICU admission.

Design: A longitudinal prospective multicenter cohort study.

Setting/patients: Patients ( n = 4092) from seven Dutch ICUs.

Discrepancy between Functional Outcomes and Perceived Health Post-Intensive Care Unit: A Prospective Cohort Study.

Despite functional impairments, intensive care unit (ICU) survivors can perceive their quality of life as acceptable. To investigate discrepancies between calculated health, based on self-reported physical, mental, and cognitive functioning and perceived health, 1 year after ICU admission. Data from an ongoing prospective multicenter cohort study, MONITOR-IC, were used.

Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors.

Background: With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors.

Methods: Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used.

One-year outcomes in COVID-19 and non-COVID-19 intensive care unit survivors.

Purpose: To determine differences in one-year multi-domain health outcomes in COVID-19 and non-COVID-19 intensive care unit (ICU) survivors.

Materials And Methods: Adult ICU survivors treated for COVID-19 were compared to a control group consisting of survivors admitted for respiratory distress due to other causes, i.e.

Abnormal Iron Status and Adverse Outcome After Elective Cardiac Surgery: A Prospective, Observational Multicenter Study.

Objectives: To investigate the incidence of preoperative abnormal iron status and its association with packed red blood cell (PRBC) transfusion, postoperative major complications, and new onset of clinically significant disability in patients undergoing elective cardiac surgery.

Design: A prospective, observational multicenter cohort study.

Setting: Three cardiac surgical centers in the Netherlands between 2019 and 2021.

Prediction of Long-Term Physical, Mental, and Cognitive Problems Following Critical Illness: Development and External Validation of the PROSPECT Prediction Model.

Objectives: ICU survivors often suffer from long-lasting physical, mental, and cognitive health problems after hospital discharge. As several interventions that treat or prevent these problems already start during ICU stay, patients at high risk should be identified early. This study aimed to develop a model for early prediction of post-ICU health problems within 48 hours after ICU admission.

Cardiac Surgery in Jehovah's Witnesses: 329 Consecutive Cases.

Objectives: This study aimed to describe the outcome of Jehovah's Witnesses (JWs) undergoing cardiac surgery at the authors' center.

Design: A single-center retrospective cohort study.

Setting: At a cardiovascular center with a tertiary intensive care unit (ICU) and specific experience with cardiac surgery in JWs.

Development and External Validation of a Prediction Model for Quality of Life of ICU Survivors: A Subanalysis of the MONITOR-IC Prospective Cohort Study.

Objectives: To develop and externally validate a prediction model for ICU survivors' change in quality of life 1 year after ICU admission that can support ICU physicians in preparing patients for life after ICU and managing their expectations.

Design: Data from a prospective multicenter cohort study (MONITOR-IC) were used.

Setting: Seven hospitals in the Netherlands.

Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records.

Purpose: To assess, validate and compare the predictive performance of models for in-hospital mortality of COVID-19 patients admitted to the intensive care unit (ICU) over two different waves of infections. Our models were built with high-granular Electronic Health Records (EHR) data versus less-granular registry data.

Methods: Observational study of all COVID-19 patients admitted to 19 Dutch ICUs participating in both the national quality registry National Intensive Care Evaluation (NICE) and the EHR-based Dutch Data Warehouse (hereafter EHR).

Mental health symptoms in family members of COVID-19 ICU survivors 3 and 12 months after ICU admission: a multicentre prospective cohort study.

Purpose: Long-term mental outcomes in family members of coronavirus disease 2019 (COVID-19) intensive care unit (ICU) survivors are unknown. Therefore, we assessed the prevalence of mental health symptoms, including associated risk factors, and quality of life (QoL) in family members of COVID-19 ICU survivors 3 and 12 months post-ICU.

Methods: A prospective multicentre cohort study in ICUs of ten Dutch hospitals, including adult family members of COVID-19 ICU survivors admitted between March 1, and July 1, 2020.

Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19.

Importance: One-year outcomes in patients who have had COVID-19 and who received treatment in the intensive care unit (ICU) are unknown.

Objective: To assess the occurrence of physical, mental, and cognitive symptoms among patients with COVID-19 at 1 year after ICU treatment.

Design, Setting, And Participants: An exploratory prospective multicenter cohort study conducted in ICUs of 11 Dutch hospitals.