Circadian rhythms in pediatric high-grade gliomas may contribute to treatment efficacy.

Pediatric high-grade gliomas (pHGG) are highly invasive with poor survival outcomes. Timing of Temozolomide administration has been shown to affect survival of adult patients with glioblastoma. We investigated whether pHGGs express circadian genes rhythmically and whether underlying rhythms affect Temozolomide sensitivity.

Cognitive Impairment Without Dementia: A Treatable Case of Dural Arteriovenous Fistula.

Dural arteriovenous fistula (DAVF) can present with a wide range of symptoms depending on its location and the degree of arteriovenous shunting. Rarely, they may manifest as cognitive impairment due to chronic venous dysfunction. This is the case of an elderly man evaluated for subacute onset of memory loss without dementia.

Transforming Cancer Care: A Narrative Review on Leveraging Artificial Intelligence to Advance Immunotherapy in Underserved Communities.

: Cancer immunotherapy has transformed oncology, but underserved populations face persistent disparities in access and outcomes. This review explores how artificial intelligence (AI) can help mitigate these barriers. : We conducted a narrative review based on peer-reviewed literature selected for relevance to artificial intelligence, cancer immunotherapy, and healthcare challenges, without restrictions on publication date.

Development and Characterization of a Novel α-Synuclein-PEST H4 Cell Line for Enhanced Drug Screening in α-Synucleinopathies.

Alpha-Synuclein (α-Syn) is a presynaptic neuronal protein implicated in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies, primarily through its aggregation into insoluble fibrils. The extended α-Syn half-life necessitates treatment durations that are incompatible with efficient high-throughput drug screening, can risk compound stability or cause cellular toxicity. To address this, we inserted a PEST sequence, a motif known to promote rapid protein degradation, at the C-terminus of the gene using CRISPR/Cas9 to create a novel cell line with reduced α-Syn half-life.

An UHPLC-HRMS-Based Untargeted Metabolomics Approach to Explore the Effects of Bacterial Endophyte Co-Culture on (L.) Tausch Cell Suspension Metabolome.

Colonization of plant tissues by bacterial endophytes might lead to qualitative and quantitative changes in secondary metabolites (SMs). In this work, in vitro co-culture experiments were performed using cell suspensions of the medicinal plant and eight of its bacterial endophytes. An untargeted metabolomics approach using Ultra-High-Performance Liquid Chromatography High-Resolution Mass Spectrometry (UHPLC-HRMS) was employed to investigate plant-microbe interactions.

Spin-Orbit Effects in a Thallium Borohydride Stabilized by Coordination to Bis(diisopropylamino)Cyclopropenylidene (BAC).

Reaction of Tl(OTf) with 2 equiv of bis(diisopropylamino)cyclopropenylidene (BAC) in THF results in formation of [Tl(BAC)(OTf)] (1) in moderate yields. Subsequent reaction of 1 with [K][H-9-BBN] ([H-9-BBN] = dihydrido 9-boratabicyclo[3.3.

Improving MRAM Performance with Sparse Modulation and Hamming Error Correction.

With the rise of the Internet of Things (IoT), smart sensors are increasingly being deployed as compact edge processing units, necessitating continuously writable memory with low power consumption and fast access times. Magnetic random-access memory (MRAM) has emerged as a promising non-volatile alternative to conventional DRAM and SDRAM, offering advantages such as faster access speeds, reduced power consumption, and enhanced endurance. However, MRAM is subject to challenges including process variations and thermal fluctuations, which can induce random bit errors and result in imbalanced probabilities of 0 and 1 bits.

Parent brain responses to child facial and vocal communication: What different methodologies reveal about parenting cognitions and practices as well as their moderation by parental status, gender, and culture as well as child characteristics.

Parenting is constituted of caregiving cognitions and practices, based in evolution and biology as well as culture and context, and lodged in nervous system structure and function. This narrative review first discusses parenting and an orientation toward caregiving in terms of its nature, constituents, and goals. Next, the review operationalizes parenting cognitions and practices that are expressed in response to facial and vocal cues of young offspring and revealed in naturalistic and experimental studies using behavioral preferences, attention tasks, and implicit association tests.

Design, synthesis and biological evaluation of novel hydroxamic acid-derived histone deacetylase inhibitors bearing a 2-oxoindoline scaffold as potential antitumor agents.

Histone deacetylases (HDACs) have emerged as compelling targets in developing anticancer therapeutics. This study outlines the development, synthesis, and biological evaluation of novel hydroxamic acid derivatives featuring a 2-oxoindoline scaffold, which exhibit high HDAC inhibitory activity and potential anticancer effects. Three series of N-hydroxycinnamamides, N-hydroxyheptanamides, and N-hydroxybenzamides were synthesized and assessed for their biological activity.

Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function.

Neuroligins (NLGNs) are a family of postsynaptic adhesion molecules that bind to their presynaptic partners, neurexins, facilitating the formation and maintenance of synapses. In humans, there are five genes encoding NLGNs (, , and ), with having highly conserved counterparts in rodents, allowing these genes to be studied with high confidence of translational validity in mouse models. Human NLGN4X and 4Y were often assumed to serve similar functions because they share a 97% sequence homology, whereas mouse NLGN4-like is quite divergent.

From Traditional to Cutting-Edge: A Review of Fetal Well-Being Assessment Techniques.

The birth of a new life, which should be a blessing to everyone, is regrettably not always the case. According to the latest data, the worldwide rate of stillbirths in 2022 stood at 13.9 stillbirths per 1,000 total births.

Synthesis of Thiazolo[5,4-]thiazoles in an Eco-Friendly L-Proline-Ethylene Glycol Mixture.

The hazardousness of solvents used in synthetic organic chemistry is well established. In this context, it is relevant to search for safer and greener alternatives. Within the last decades, deep eutectic solvents have been considered as possible and promising alternatives.

Characterization of Important Odorants from Shell Ginger Rhizomes, .

Shell ginger, (Pers.) B.L.

Influence of supporting teeth quantity of surgical guide on the accuracy of the immediate implant in the maxillary central incisor: an in vitro study.

Introduction: Guided surgery for immediate anterior implants aims to reduce the time required for aesthetic and functional immediate loading. However, the limited surface area of anterior teeth for guide stabilization may affect the accuracy of implant positioning. This in vitro study evaluated the effect of the number of supporting teeth on the accuracy of immediate implants in the maxillary central incisor region.

Comfort Foods in the Twenty-First Century: Friend or Foe?

The comfort food (CF) concept emerged during the latter half of the twentieth century. Although not well defined, CF can be described as familiar foods that elicit feelings of well-being and play a role in social interactions and psychological health. These foods are often calorically dense and nutrient-poor, and overconsumption of some CF may contribute to negative metabolic health outcomes.

A Non-Contacted Height Measurement Method in Two-Dimensional Space.

Height is an important health parameter employed across domains, including healthcare, aesthetics, and athletics. Numerous non-contact methods for height measurement exist; however, most are limited to assessing height in an upright posture. This study presents a non-contact approach for measuring human height in 2D space across different postures.

Evaluating a generative artificial intelligence accuracy in providing medication instructions from smartphone images.

Background: The Food and Drug Administration mandates patient labeling materials like the Medication Guide (MG) and Instructions for Use (IFU) to support appropriate medication use. However, challenges such as low health literacy and difficulties navigating these materials may lead to incorrect medication usage, resulting in therapy failure or adverse outcomes. The rise of generative AI, presents an opportunity to provide scalable, personalized patient education through image recognition and text generation.

A Wireless and Wearable Multimodal Sensor to Non-Invasively Monitor Transabdominal Placental Oxygen Saturation and Maternal Physiological Signals.

Poor placental development and placental defects can lead to adverse pregnancy outcomes such as pre-eclampsia, fetal growth restriction, and stillbirth. This study introduces two sensors, which use a near-infrared spectroscopy (NIRS) technique to measure placental oxygen saturation transabdominally. The first one, an NIRS sensor, is a wearable device consisting of multiple NIRS channels.

Evaluation of a multimodal ctDNA-based assay for detection of aggressive cancers lacking standard screening tests.

Cancers lacking standard screening (LSS) options account for approximately 70% of cancer-related deaths due to late-stage diagnosis. Circulating tumor DNA (ctDNA) is a promising biomarker for multi-cancer early detection. We previously developed SPOT-MAS, a multimodal ctDNA-based assay analyzing methylation and fragmentomic profiles, effective in detecting common cancers (breast, colorectal, liver, lung and gastric).

Characterization of Odorants in Clustered Mountain Mint .

The clustered mountain mint, , is a pleasant-smelling, native North American plant. Despite its wide geographical presence across the United States and Canada, little is known about the specific odorants responsible for its pleasing aroma. Herein, 42 odorants were identified in the plant through solvent-assisted flavor evaporation (SAFE), gas chromatography-olfactometry (GC-O), and gas chromatography-mass spectrometry (GC-MS).

Advancing sustainable rice production in the Vietnamese Mekong Delta insights from ecological farming systems in An Giang Province.

Rice serves as a crucial staple food crop for half of the world's population. In the Vietnamese Mekong Delta (VMD), rice production plays a vital role in national food security. However, the majority of the existing intensified rice cultivation schemes in the VMD, which are typically traditional, have rendered many farmers' livelihoods unsustainable due to issues such as land degradation, water pollution, health risks, and low profitability.