Publications by authors named "Thi-Hoang-Oanh Duong"
Article Synopsis
- The study investigates the combined effects of natural killer (NK) cells, bevacizumab (Bev), and irinotecan (Iri) on glioblastoma multiforme (GBM) in order to tackle the diverse nature of tumor cells.
- Researchers found that while Iri promotes both GBM cell proliferation and NK ligand expression, Bev does not significantly alter these processes but can enhance Iri's effect.
- The results show that injecting NK cells, especially directly into the tumor, improves the cytotoxic response against Bev and Iri-treated GBM cells, resulting in reduced tumor growth in a mouse model.
Glioblastoma, the most common aggressive cancer, has a poor prognosis. Among the current standard treatment strategies, radiation therapy is the most commonly recommended. However, it is often unsuccessful at completely eliminating the cancer from the brain.
View Article and Find Full Text PDFRecent clinical trials utilizing antigen-pulsed dendritic cells (DCs) have demonstrated increased survival of vaccinated cancer patients. Besides, the cytoplasmic transduction peptide (CTP) not only has an excellent transcellular efficiency but also shows a strong tendency to remain in the cytoplasm after transduction, without migrating into the nucleus. In this study, we investigated the effectiveness of immunotherapy against malignant gliomas using DCs pulsed with CTP-fused protein antigens combined with programmed cell death protein 1 blockade (anti-PD1).
View Article and Find Full Text PDF