Gestational alloimmune liver disease treated with intravenous immunoglobulin resulting in maternal drug-induced liver injury.

Gestational alloimmune liver disease (GALD) is a rare pregnancy complication involving maternal antibody-mediated fetal liver injury that recurs in 90% of affected pregnancies. The fetal and neonatal mortality rate is high, up to 82%, and affected fetuses can develop fetal hydrops, growth restriction, and oligohydramnios. Intravenous immunoglobulin (IVIG) administration can prevent GALD recurrence.

Trait mindfulness in early pregnancy and adverse perinatal outcomes: a prospective cohort study.

Background: Mindfulness centered therapy has been shown to improve perinatal mental health outcomes. There is emerging evidence that mindfulness training (MT) can also be harnessed to improve somatic outcomes. Yet, little is known about which perinatal populations might benefit the most from mindfulness training interventions.

Vascular Placental Pathology and Cardiac Structure in Stillborn Fetuses.

Objective:  Adverse pregnancy outcomes, including preterm birth and preeclampsia, are associated with worse cardiovascular outcomes for offspring. Examination of the placenta is important for understanding how the prenatal period shapes long-term cardiovascular health. We sought to investigate the association between placental vascular malperfusion and fetal cardiac structure.

Proactive Coping in Early Pregnancy and Adverse Pregnancy Outcomes.

Objective: Outside of pregnancy, proactive coping has been associated with both mental and physical well-being and with improved quality of life in chronic disease, but its effects in pregnancy are understudied. Our objective was to evaluate whether early pregnancy proactive coping was associated with adverse perinatal outcomes.

Study Design: This was a planned secondary analysis of nulliparous pregnant people recruited from a tertiary care center.

Early-Pregnancy Resilience Characteristics before versus during the COVID-19 Pandemic.

Objective:  Resilience is associated with mental and somatic health benefits. Given the social, physical, and mental health toll of the coronavirus disease 2019 (COVID-19) pandemic, we examined whether the COVID-19 pandemic was associated with population-level changes in resilience among pregnant people.

Study Design:  Secondary analysis of a prospective cohort of nulliparous pregnant people <20 weeks' gestation from a single hospital.

Placental Lesions Associated With Stillbirth by Gestational Age, as Related to Cause of Death: Follow-Up Results From the Stillbirth Collaborative Research Network.

Background: We previously identified placental lesions associated with stillbirths of varying gestational ages (GA) using advanced feature analysis. We further investigated the relationships between placental lesions and cause of death in stillbirths within these GA ranges.

Methods: Using data from the Stillbirth Collaborative Research Network, we derived a sample of stillbirths who underwent placental examination and Initial Causes of Fetal Death (INCODE) evaluation for determining cause of death.

Early pregnancy dispositional optimism and pregnancy outcomes among nulliparous people.

Background: Dispositional optimism, the expectation of positive outcomes after personal challenges, is a resilience factor associated with widespread health benefits. However, the data on pregnancy-related outcomes are more limited.

Objective: This study aimed to assess the association of early pregnancy dispositional optimism with adverse perinatal outcomes.

Assessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach.

Previous studies identified microscopic changes associated with intrauterine retention of stillbirths based on clinical time of death. The objective of this study was to utilize unsupervised machine learning (not reliant on subjective measures) to identify features associated with time from death to delivery. Data were derived from the Stillbirth Collaborative Research Network.

Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination.

Introduction: Lesions of maternal vascular malperfusion (MVM) and fetal vascular malperfusion (FVM) are common in placentas associated with both stillbirth and live birth. The objective of this study was to identify lesions present more commonly in stillborn placentas and those most indicative of MVM and FVM without microscopic pathologic evaluation.

Methods: Data were derived from the Stillbirth Collaborative Research Network.

Identifying risk of stillbirth using machine learning.

Background: Previous predictive models using logistic regression for stillbirth do not leverage the advanced and nuanced techniques involved in sophisticated machine learning methods, such as modeling nonlinear relationships between outcomes.

Objective: This study aimed to create and refine machine learning models for predicting stillbirth using data available before viability (22-24 weeks) and throughout pregnancy, as well as demographic, medical, and prenatal visit data, including ultrasound and fetal genetics.

Study Design: This is a secondary analysis of the Stillbirth Collaborative Research Network, which included data from pregnancies resulting in stillborn and live-born infants delivered at 59 hospitals in 5 diverse regions across the United States from 2006 to 2009.

Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network.

Introduction: Previous studies have identified lesions commonly found in placentas associated with stillbirth but have not distinguished across a range of gestational ages (GAs). The objective of this study was to identify lesions associated with stillbirths at different GAs by adapting methods from the chemical machine learning field to assign lesion importance based on correlation with GA.

Methods: Placentas from the Stillbirth Collaborative Research Network were examined according to standard protocols.

Related amyloid burden and cortical atrophy in individuals with subtle cognitive decline.

Background And Purpose: Subtle cognitive decline represents a stage of cognitive deterioration in which pathological biomarkers may be present, including early cortical atrophy and amyloid deposition. Using individual items from the Montreal Cognitive Assessment and k-modes cluster analysis, we previously identified three clusters of individuals without overt cognitive impairment: (1) High Performing (no deficits in performance), (2) Memory Deficits (lower memory performance), and (3) Compound Deficits (lower memory and executive function performance). In this study, we sought to understand the relationships found in our clusters between cortical atrophy on MR and amyloid burden on PET.

Association of Perceived Lack of Paternal Support After Stillbirth With Maternal Postpartum Depression or Anxiety.

This cross-sectional study examines the incidence of postpartum depression and anxiety in women who perceive a lack paternal support after stillbirth.

Holding a baby after stillbirth: the impact of fetal congenital and structural abnormalities.

Objective: Stillbirth can result in numerous adverse psychosocial sequelae. Recommendations vary with regard to holding the baby after a stillbirth. Few studies have addressed the impact of fetal abnormalities on these outcomes.

Dispositional Optimism, Mode of Delivery, and Perceived Labor Control among Recently Delivered Parturients.

Objective: Dispositional optimism (DO) is an understudied transdiagnostic resilience factor among peripartum individuals. Low DO is associated with increased fear and pain in labor and increased rates of emergent cesarean delivery, but it is unknown whether DO is associated with perceived control over the labor process.

Study Design: This a planned secondary analysis of a prospective observational cohort of term parturients ( = 164) who were recruited in July and August 2021 during their delivery hospitalization at a single, tertiary medical center.

Using the Montreal cognitive assessment to identify individuals with subtle cognitive decline.

Objective: Dementia is a devastating neurological disease that may be better managed if diagnosed earlier when subclinical neurodegenerative changes are already present, including subtle cognitive decline and mild cognitive impairment. In this study, we used item-level performance on the Montreal Cognitive Assessment (MoCA) to identify individuals with subtle cognitive decline.

Method: Individual MoCA item data from the Alzheimer's Disease Neuroimaging Initiative was grouped using -modes cluster analysis.

Intrauterine Fetal Demise Associated with Vascular Malperfusion and Multiple Uterine Leiomyomata: A Report of Two Cases.

Background: Uterine leiomyomata have been loosely associated with intrauterine fetal demise (IUFD), largely attributed to fetal growth restriction from cavitary distortion. We present two cases of IUFD in patients with non-distorting leiomyomata and pathologic placental findings of maternal vascular malperfusion (MVM) and fetal vascular malperfusion (FVM).

Case Report: Case 1 details a 28w3d IUFD associated with large leiomyomata (largest 11.

Derivation and Validation of a Predictive Algorithm for Long-Term Care Admission or Death.

Objectives: Older veterans prefer to remain in their homes and communities as long as possible. Although targeted delivery of home- and community-based services for veterans might delay long-term care placement, often, access to these services is inconsistently organized or delayed. To aid in early recognition of veterans at high risk for long-term care placement or death, we developed and validated a predictive algorithm, "Choose Home.

Prospective Longitudinal Study of Gait and Balance in a Cohort of Elderly Essential Tremor Patients.

Essential tremor (ET) encompasses a variety of features, including tremor, cognitive dysfunction, and gait and balance impairments. Gait and balance impairments in ET are often mild, but they can be severe and are, in some cases, associated with functional sequelae in terms of increased fall risk and reduced balance confidence. Previous research on gait and balance in ET has been limited to cross-sectional comparisons.

Rate of progression from mild cognitive impairment to dementia in an essential tremor cohort: A prospective, longitudinal study.

Background: Essential tremor (ET), among the most common neurological diseases, is associated with cognitive dysfunction. Yet, nearly all knowledge of ET-related cognitive impairment is static and cross-sectional (e.g.

The "Caring Giver": Emotional Caregiving in the Setting of Essential Tremor.

Introduction: Essential tremor (ET) is a common neurological disorder associated with functional impairment. Emerging evidence shows that some ET caregivers experience burden, but the unique interpersonal aspects of caregiving in the context of ET have not been fully examined.

Research Design: Open-ended questions were administered to 98 ET care-recipient-caregiver dyads.

Enfeeblement in Elders with Essential Tremor: Characterizing the Phenomenon and Its Role in Caregiver Burden.

Background: Individuals with essential tremor (ET), a common movement disorder, experience functional impairment, which contributes to burden experienced by their loved ones and caregivers. Some burdened caregivers report their loved ones as seeming debilitated or prematurely old, a concept that we have called . Using the Essential Tremor Enfeeblement Survey (ETES), we seek to characterize enfeeblement in elders with ET and assess its contribution to caregiver burden.

Profiles of Normal Cognition in Essential Tremor.

Objectives: Patients with essential tremor exhibit heterogeneous cognitive functioning. Although the majority of patients fall under the broad classification of cognitively "normal," essential tremor is associated with increased risk for mild cognitive impairment and dementia. It is possible that patterns of cognitive performance within the wide range of normal functioning have predictive utility for mild cognitive impairment or dementia.