DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition.

Base excision repair, initiated by DNA glycosylases, preserves genomic integrity by removing damaged bases. DNA glycosylases Ogg1 and Mutyh were shown to alter the hippocampal transcriptome independently of DNA damage repair. However, the role of DNA glycosylases as transcriptional regulators and their involvement in cognition remain unclear.

Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH.

8-oxo-7,8-dihydroguanine (OG) is one of the most abundant oxidative lesions in the genome and is associated with genome instability. Its mutagenic potential is counteracted by a concerted action of 8-oxoguanine DNA glycosylase (OGG1) and mutY homolog DNA glycosylase (MUTYH). It has been suggested that OG and its repair has epigenetic-like properties and mediates transcription, but genome-wide evidence of this interdependence is lacking.

Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease.

Oxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating repair of oxidative DNA base lesions and with a distinct expression pattern in proliferating cells.

Organization of Posterior Parietal-Frontal Connections in the Rat.

Recent investigations of the rat posterior parietal cortex (PPC) suggest that this region plays a central role in action control together with the frontal cortical areas. Posterior parietal-frontal cortical connections have been described in rats, but little is known about whether these connections are topographically organized as in the primate. Here, we injected retrograde and anterograde tracers into subdivisions of PPC as well as the frontal midline and orbital cortical areas to explore possible topographies within their connections.

What Can We Learn About Psychopathic Offenders by Studying Their Communication? A Review of the Literature.

Experts have long warned against psychotherapy with psychopathic offenders out of a fear that they will beguile therapists into believing they have been rehabilitated, only to commit new offenses upon release. Yet the question is not whether to communicate with psychopathic offenders, but rather how to do so in a way which can facilitate real change. In this article, we ask: What can we learn about psychopathic offenders by studying their communication? We review the literature and describe how psychopathy is manifested in communication, how psychopathy can be understood based on this communication, and how therapists may communicate with psychopaths to create change and avoid being fooled.