IBSP mediates fibroblast malignant behaviors in hypertrophic scars via interacting with SKP1.

Aims: Hypertrophic scars (HS) are fibrotic skin conditions marked by abnormal myofibroblast proliferation and extracellular matrix accumulation. This study aimed to elucidate the functional effects and potential mechanisms of integrin-binding sialoprotein (IBSP) in hypertrophic scar fibroblasts.

Materials And Methods: IBSP protein and wnt signaling pathway were screened by transcriptomics.