Publications by authors named "Teemu Martikainen"
Objective: Physical exercise-especially at high intensity-is known to impose cardiac stress, as mirrored by, e.g., increased blood levels of cardiac stress biomarkers such as cardiac Troponin T (cTnT) and NT-proBNP.
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- The COVID-19 pandemic has led to changes in lifestyle and work habits, impacting sleep timing and potentially increasing the risk of insomnia symptoms.
- In a survey of nearly 15,000 participants across 14 countries, researchers analyzed the relationship between social jetlag (the difference in sleep timing on work vs. free days) and insomnia symptoms, controlling for various confounding factors.
- Results showed that both increases and decreases in social jetlag were linked to later sleep times and higher rates of insomnia symptoms, particularly among those who reduced their social jetlag, suggesting that stability in sleep/wake timing is crucial for preventing insomnia.
The hormone fibroblast growth factor 21 (FGF21) modulates tissue metabolism and circulates at higher levels in metabolic conditions associated with chronic sleep-wake disruption, such as type 2 diabetes and obesity. In the present study, we investigated whether acute sleep loss impacts circulating levels of FGF21 and tissue-specific production, and response pathways linked to FGF21. A total of 15 healthy normal-weight young men participated in a randomised crossover study with two conditions, sleep loss versus an 8.
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- Tumor-draining lymph nodes (TDLNs) are crucial for both inducing anti-tumor immunity and serving as common sites for cancer metastasis.
- Researchers found that in breast cancer patients, particularly those with invasive types, TDLNs exhibited significant structural and molecular changes in high endothelial venules (HEVs), which are vital for immune cell recruitment.
- These HEV alterations were linked to disrupted signaling in surrounding cells and the accumulation of specific immune cells, indicating that changes in TDLNs could serve as potential biomarkers for assessing tumor invasiveness and immune response.