Publications by authors named "Taylor deVet"
Despite the wide body of research into prevention and treatment of nonunion, current bone fracture therapies remain suboptimal in their efficacy. Previous animal studies show that MES-1022, a bone-targeted prodrug that activates the prostaglandin E2 receptor EP4, stimulates bone healing when applied locally in uneventful defects. Here we investigated the healing capacity of systemically administered MES-1022 in a rat femoral critical size segmental defect.
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- Marfan syndrome (MFS) is linked to mutations in the FBN1 gene, affecting fibrillin-1, a protein crucial for bone structure and growth factor regulation, leading to skeletal issues like low bone density and long bone overgrowth.
- A study used a mouse model of MFS to analyze various aspects of bone structure and behavior, including curvature, composition, and mechanical properties across different ages of mice.
- Results indicated that while MFS mice exhibited traits consistent with the syndrome, such as long bone overgrowth and reduced trabecular thickness, their overall mechanical and structural properties were similar to control mice, with some differences in bone matrix crystallinity and porosity.
Bone Bioelectricity and Bone-Cell Response to Electrical Stimulation: A Review.
Crit Rev Biomed Eng
November 2021
It is hypothesized that bone cells can sense mechanical force in the extracellular network via an electrical signal. This has led to the use of electrical stimulation (ES) to improve fracture repair and mitigate bone loss. Although overlap exists in bone maintenance and fracture healing mechanics, the processes involved in both are very different, resulting in dissimilar behaviors from the cells.
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