Thrombophilic Mutations Among Patients with Sickle Cell Disease.

Background: Factor V-Leiden (FVL), Prothrombin (PRT) G20210A, and Methylene Tetrahydro Folate Reductase (MTHFR) C677T and A1298C mutations are major inherited risk factors of thrombotic complications. Our aim in this study was to investigate the prevalence of these mutations among Tunisian sickle cell patients.

Methods: Study subjects comprised 64 patients and 100 healthy controls.