Publications by authors named "Szimonetta Komjathine Szepligeti"
Prenatal and Early-Life Anti-Infectives and Obesity at Age 7 Years.
Pharmacoepidemiol Drug Saf
November 2024
Article Synopsis
- A study was conducted to explore the link between prenatal and early-life exposure to anti-infectives and the risk of obesity in children at age 7, using data from a large Danish population registry.
- Researchers found that children exposed to anti-infectives showed a significant increase in obesity prevalence, with exposure during infancy having a more pronounced effect compared to prenatal exposure.
- The results indicate that the risk of obesity rises with the number of anti-infective prescriptions, suggesting a potential correlation between these medications taken early in life and childhood obesity.
Patient characteristics, treatment patterns, and survival outcomes for patients with malignant pleural mesothelioma in Denmark between 2011 and 2018: a nationwide population-based cohort study.
Acta Oncol
August 2024
Background: Malignant pleural mesothelioma (MPM) is a rare thoracic malignancy with poor prognosis and limited treatment options. Immunotherapy shows potential for improved outcomes; however, real-world evidence on its use will take time to accumulate. This study examined patient characteristics, treatment patterns, overall survival (OS), and predictors of mortality among patients diagnosed with MPM in Denmark prior to the introduction of newer treatments.
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- This study investigates how comorbidities (other health conditions) affect mortality rates after cardiac arrest, revealing that a higher burden of comorbidities significantly increases the risk of death.
- The research utilized a large Danish cohort of patients hospitalized for cardiac arrest from 1996 to 2021 and compared them with a matched control group from the general population, analyzing their mortality rates based on their comorbidity status.
- Results show that the impact of comorbidities on mortality is substantial, with interaction effects causing an increase in mortality rates that went beyond the individual effects of cardiac arrest and comorbidities alone.
Incidence rate of venous thrombosis in women switching combined oral contraceptives: a cohort study.
Res Pract Thromb Haemost
March 2024
Background: The incidence rate of venous thrombosis (VT) in women switching combined oral contraceptives (COCs) is unknown.
Objectives: We hypothesize that women switching COCs may have a similar increased incidence rate of VT as women who start COCs. Switching means starting with a new COC, which may biologically approximate starting.
Risk of Bleeding and Venous Thromboembolism after Colorectal Cancer Surgery in Patients with and without Type 2 Diabetes: A Danish Cohort Study.
TH Open
January 2024
Bleeding and venous thromboembolism (VTE) are adverse outcomes after colorectal cancer (CRC) surgery. Type 2 diabetes (T2D) clusters with bleeding and VTE risk factors. We examined the bleeding and VTE risk in patients with T2D undergoing CRC surgery and the prognosis after these adverse outcomes.
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- The study aimed to assess the risks associated with prenatal exposure to the antiepileptic drug pregabalin, focusing on adverse birth outcomes and neurodevelopmental issues in children.
- Data was collected from population-based registries across Denmark, Finland, Norway, and Sweden from 2005 to 2016, comparing outcomes between those exposed to pregabalin and those not exposed, as well as against other medications like lamotrigine and duloxetine.
- Results indicated that while there were some associations observed, such as an increased risk for stillbirth and ADHD, overall, pregabalin exposure did not significantly correlate with serious birth issues like low birth weight, preterm birth, or developmental disorders.
Background: Type 2 diabetes and obesity may be inversely associated with amyotrophic lateral sclerosis (ALS), but the evidence is controversial.
Methods: Using Danish, nationwide registries (1980-2016), we identified patients with a diagnosis of type 2 diabetes (N = 295,653) and patients with a diagnosis of obesity (N = 312,108). Patients were matched (1:3) to persons from the general population on birth year and sex.
Tuberculosis (TB) is a risk factor for chronic obstructive pulmonary disease (COPD), but COPD is also a predictor of TB. The excess life-years lost to COPD caused by TB can potentially be saved by screening for and treating TB infection. We examined the number of life-years that could be saved by preventing TB and TB-attributable COPD.
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- * It involved a large cohort of nearly 182,000 MI patients compared to nearly 910,000 matched individuals without MI, focusing on outcomes over a 21-year follow-up period.
- * The results showed that MI patients had a 20% lower risk of Parkinson disease and a 28% lower risk of secondary parkinsonism, suggesting a possible link between cardiovascular health and reduced risk of these neurological conditions.
Importance: Influenza has been associated with the risk of developing Parkinson disease, but the association is controversial.
Objective: To examine whether prior influenza and other infections are associated with Parkinson disease more than 10 years after infection.
Design, Setting, And Participants: This case-control study used data from 1977 to 2016 from the Danish National Patient Registry.
Objectives: To assess the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter and heart failure in patients with constipation compared with a general population cohort.
Design: Population-based matched cohort study.
Setting: All Danish hospitals and hospital outpatient clinics from 2004 to 2013.
Objectives: We investigated combined hormonal contraceptives (CHC) prescribing patterns (focusing on combined oral contraceptives; COC) in three countries (Netherlands, Denmark, United Kingdom) in a time period preceding and in a time period following the European Commission's decision to update product information, and we estimated changes in incidence of venous thromboembolism (VTE) between the two periods.
Study Design: We conducted a drug utilization analysis and a cohort study using routinely collected data. We calculated number, proportion and incidence rate of new users, switchers, and stoppers of COC in both time periods.
Background: Myocardial infarction (MI) is a risk factor for venous thromboembolism (VTE). Although comorbidities affect MI prognosis, it is unclear whether they affect VTE risk after MI.
Objectives: We examined the impact of comorbidity on VTE risk after MI.
Patterns of initial migraine treatment in Denmark: A population-based study.
Pharmacoepidemiol Drug Saf
March 2019
Purpose: Population-based data are sparse on utilization of prophylactic versus acute therapies for newly diagnosed migraine. We examined initial migraine treatment patterns and associated patient characteristics in Denmark.
Methods: We used population-based health databases to assemble a nationwide cohort of adult migraine patients in 2005 to 2013.
Objective: To examine the risks of myocardial infarction, stroke (ischaemic and haemorrhagic), peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure in patients with migraine and in a general population comparison cohort.
Design: Nationwide, population based cohort study.
Setting: All Danish hospitals and hospital outpatient clinics from 1995 to 2013.
Prediction of mortality in patients with chronic obstructive pulmonary disease with the new Global Initiative for Chronic Obstructive Lung Disease 2017 classification: a cohort study.
Lancet Respir Med
March 2018
Article Synopsis
- The study investigated how the GOLD 2017 classification for chronic obstructive pulmonary disease (COPD) predicts mortality compared to earlier classifications (2007 and 2011) using both symptom groups (ABCD) and spirometric stages (1-4).
- A cohort of 33,765 COPD patients from Danish outpatient clinics was analyzed, focusing on their health data and mortality rates over time.
- The findings aimed to reveal the effectiveness of the new classification system in predicting both overall and respiratory-specific mortality.
Background: A principle of cohort studies is that cohort membership is defined by current rather than future exposure information. Pharmacoepidemiologic studies using existing databases are vulnerable to violation of this principle. We evaluated the impact of using data on future redemption of prescriptions to determine cohort membership, motivated by a published example seeking to emulate a "per-protocol" association between continuous versus never use of low-dose acetylsalicylic acid (ASA) and major bleeding (e.
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