Publications by authors named "Sylvain Jeannin"
During mitosis, the microtubule depolymerase KIF2C, the tumor suppressor BRCA2, and the kinase PLK1 contribute to the control of kinetochore-microtubule attachments. Both KIF2C and BRCA2 are phosphorylated by PLK1, and BRCA2 phosphorylated at T207 (BRCA2-pT207) serves as a docking site for PLK1. Reducing this interaction results in unstable microtubule-kinetochore attachments.
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- The loading of the bacterial helicase DnaB for genome replication relies on accessory proteins, particularly DciA, which is not well understood.
- Research showed that DciA from Vibrio cholerae forms fluid condensates when interacting with single-stranded DNA, displaying phase separation behavior.
- DnaB is recruited to these condensates while DciA is released, and similar behavior is observed with the helicase loader DnaC from E. coli, suggesting that DciA may help create non-membrane compartments for DNA replication.