Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants in the Extended Treatment of Venous Thromboembolism: A Systematic Review and Meta-Analysis.

Purpose: The optimal dosing strategy for direct oral anticoagulants (DOACs) in extended treatment of venous thromboembolism (VTE) remains debated, particularly in balancing efficacy and bleeding risk.

Methods: A systematic review and meta-analysis was performed to compare reduced-dose versus full-dose DOACs for extended VTE treatment. Databases including PubMed, Embase, and Cochrane Library were searched from inception to March 2025 for randomized controlled trials (RCTs) involving adult patients treated with different DOAC doses for VTE.

Sarcopenia in chronic obstructive pulmonary disease: mechanisms, diagnosis, and management strategies.

Sarcopenia affects 20%-40% of chronic obstructive pulmonary disease (COPD) patients, significantly reducing muscle strength and functional capacity, leading to a decline in quality of life. This study reviews the impact of sarcopenia in COPD and evaluates effective therapeutic strategies. Findings suggest that pulmonary rehabilitation, combined with aerobic and resistance exercises, and supplemented with protein and vitamin D, enhances muscle function and reduces the prevalence of sarcopenia.

Type II Kounis syndrome triggered by iodinated contrast during coronary angioplasty: A case report and clinical insights.

Introduction And Importance: Kounis syndrome or "allergic angina" or "allergic myocardial infarction" is acute coronary syndrome that results from hypersensitivity reactions. It may also result from interventions involving the use of iodinated contrast media in patients with previous coronary artery disease. Early treatment and diagnosis prevent severe cardiovascular implications.

Bridging surgical oncology and personalized medicine: the role of artificial intelligence and machine learning in thoracic surgery.

Lung cancer remains the leading cause of cancer-related deaths globally, often detected in advanced stages with poor prognosis. While surgical resection is the mainstay of curative treatment, early detection remains a significant challenge. Advances in personalized medicine, including genomic profiling and low-dose CT scans, have led to more tailored therapies, offering improved outcomes.

Efficacy and safety of FcRn inhibitors in patients with Myasthenia gravis: An updated systematic review and meta‑analysis.

Background: Myasthenia gravis (MG) is a chronic, complex autoimmune disorder characterized by the production of autoantibodies that destroy neuromuscular junctions. Blocking the neonatal Fc receptors (FcRn) enhances IgG catabolism, offering a novel therapeutic approach.

Methods: PubMed, Embase, and the Cochrane Library were searched up to February 2025, for RCTs evaluating FcRn inhibitors in MG.

Unveiling the silent threat of new onset atrial fibrillation in covid-19 hospitalized patients: A retrospective cohort study.

Background: COVID-19, a highly infectious respiratory disease, has been associated with a range of cardiovascular complications. One of the most commonly reported cardiovascular issues in COVID-19 patients is the development of arrhythmias. Among all types of arrhythmias, atrial fibrillation is the most frequently observed.