Cholesterol homeostasis and pathway enrichment in post-revascularization recovery.

Background: Heart revascularization is a critical intervention for restoring myocardial perfusion in patients with ischemic cardiovascular disease. While the procedure alleviates ischemia, it also triggers systemic metabolic and transcriptional changes, particularly in lipid metabolism.

Methods: In this pilot study, we utilized RNA-seq data from 4 revascularized patients and 5 control participants from the Qatar Biobank (QBB) to investigate the effects of revascularization on cholesterol biosynthesis and metabolic pathways.

COVID-19Base v3: Update of the knowledgebase for drugs and biomedical entities linked to COVID-19.

COVID-19 has taken a huge toll on our lives over the last 3 years. Global initiatives put forward by all stakeholders are still in place to combat this pandemic and help us learn lessons for future ones. While the vaccine rollout was not able to curb the spread of the disease for all strains, the research community is still trying to develop effective therapeutics for COVID-19.

Machine learning based personalized drug response prediction for lung cancer patients.

Lung cancers with a mutated epidermal growth factor receptor (EGFR) are a major contributor to cancer fatalities globally. Targeted tyrosine kinase inhibitors (TKIs) have been developed against EGFR and show encouraging results for survival rate and quality of life. However, drug resistance may affect treatment plans and treatment efficacy may be lost after about a year.