Publications by authors named "Sydney J Risen"
Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer's disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-associated neuroinflammation is the NF-κB and NLRP3 signaling axis. However, current treatments targeting NF-κB or NLRP3 may have adverse/systemic effects, and most have not been clinically translatable.
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- * The research aimed to combat neuroinflammation by targeting the NF-κB transcription factor and NLRP3 inflammasome protein using a new RNA-based treatment, SB_NI_112, which is safe and effectively penetrates the brain.
- * Treatment with SB_NI_112 in prion-diseased mice resulted in reduced inflammation, preserved neurons, improved cognitive function, and increased lifespan, suggesting potential for similar applications in other neurodegenerative diseases, despite limitations in the study.
Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer's disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-associated neuroinflammation is the NF-κB and NLRP3 signaling axis. However, current treatments targeting NF-κB or NLRP3 may have adverse/systemic effects, and most have not been clinically translatable.
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