Publications by authors named "Swarnima Gupta"
Article Synopsis
- - Leishmania parasites manipulate host macrophages by decreasing the level of Dicer, which leads to upregulation of host proteins Rab18 and TRAPPC9, promoting fatty acid acquisition from lipid-bodies (LBs).
- - The parasite downregulates miR-1914-3p, which normally suppresses Rab18 and TRAPPC9, allowing Leishmania to recruit these proteins to their parasitophorous vacuoles (Ld-PVs).
- - Introducing miR-1914-3p into macrophages can inhibit LB recruitment and reduce the growth of Leishmania, highlighting a critical mechanism for the parasite's fatty acid acquisition necessary for its survival.
CD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e.
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