Publications by authors named "Swapnil Chandrakant Devarkar"
Article Synopsis
- HIV-1 inhibitors Bevirimat (BVM) and Lenacapavir (LEN) work by blocking the production and maturation of infectious viral particles, but their exact mechanisms were not well understood due to limited structural data.
- Using perforated virus-like particles from mammalian cells, researchers utilized cryo-electron microscopy to achieve high-resolution structures of HIV-1 with BVM and LEN, marking the first detailed view of these inhibitors interacting with the immature virus.
- The study revealed how BVM binds to the Gag lattice and showed that LEN not only targets the mature capsid but also the immature lattice, causing significant changes in the capsid protein and Gag structure, which might influence the virus's maturation process.
