Publications by authors named "Svenja K Tetzlaff"
Article Synopsis
- Glioblastomas are aggressive brain tumors that resist treatment and utilize neuron-tumor connections to promote their growth, with cholinergic neurons playing a key role in this invasion.
- The study utilized rabies viruses for retrograde tracing to reveal how glioblastomas integrate into brain circuits, showing that radiotherapy can enhance neuron-tumor connectivity, complicating treatment efforts.
- By disrupting neuron-tumor connections, researchers discovered a potential therapeutic approach that could halt glioblastoma progression, emphasizing the need to target these synapses for better treatment outcomes.
Article Synopsis
- Intravital 2P-microscopy facilitates the study of brain tumor behavior in mouse cortex, previously limited by imaging challenges in deep brain areas.
- The new Deep3P imaging workflow combines microscopy with artificial intelligence, allowing researchers to visualize glioblastoma infiltrating up to 1.2 mm into the brain.
- The study reveals that glioblastoma primarily invades through blood vessels in the white matter, and identifies potential imaging biomarkers associated with early tumor colonization.
Diffuse gliomas, particularly glioblastomas, are incurable brain tumours. They are characterized by networks of interconnected brain tumour cells that communicate via Ca transients. However, the networks' architecture and communication strategy and how these influence tumour biology remain unknown.
View Article and Find Full Text PDFGlioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma cells forms a functional and therapy-resistant tumor cell network interconnected by tumor microtubes (TMs). Other subpopulations appear unconnected, and their biological role remains unclear.
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