Publications by authors named "Suzanne Arulogun"
Nodal Peripheral T-Cell Lymphoma: Therapeutic Challenges and Future Perspectives.
Cancers (Basel)
March 2025
Peripheral T-cell lymphomas (PTCLs) present a significant clinical challenge despite recent advances in the development of novel therapeutic agents, guided by a deeper understanding of the pathobiology and the genetic and molecular characteristics underlying this complex and heterogeneous group of aggressive non-Hodgkin lymphomas (NHLs) [...
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- The Consensus Panel 1 (CP1) of IWWM-11 focused on updating guidelines for managing symptomatic, treatment-naïve Waldenstrom's Macroglobulinemia (WM) patients, asserting that watchful waiting is best for asymptomatic cases.
- Current first-line treatments include chemoimmunotherapy regimens like DRC and Benda-R, which are effective, usually well-tolerated, and cost-effective; covalent BTK inhibitors like zanubrutinib also provide a viable alternative, showing fewer side effects and better remissions compared to ibrutinib.
- The panel also noted the importance of testing for MYD88 and CXCR4 mutations prior to treatment, as these can influence the effectiveness of certain
Article Synopsis
- Bendamustine and rituximab (BR) therapy is effective for treating Waldenström Macroglobulinemia (WM), but the optimal dose of Bendamustine and its effects in different treatment settings remain unclear.
- In a study of 250 WM patients, response rates were significantly better in patients treated in the frontline setting compared to those with relapsed disease (91.4% vs 73.9%).
- Achieving a complete response (CR) or very good partial response (VGPR) improved survival rates, and higher doses of Bendamustine were linked to better progression-free survival (PFS) outcomes in both frontline and relapsed patients.
Bing-Neel syndrome is a rare neurological complication of Waldenström macroglobulinemia. We present the case of a 71-year-old man who underwent prechemotherapy and postchemotherapy FDG PET/MRI scan for the evaluation of cerebrospinal disease. In light of limited literature and lack of consensus guidelines on the role of metabolic imaging, we aim to highlight the utility of FDG PET/MRI in the diagnosis and response assessment in Bing-Neel syndrome.
View Article and Find Full Text PDFExtracorporeal photopheresis for the treatment of Sézary syndrome using a novel treatment protocol.
J Am Acad Dermatol
October 2008
Various studies have reported that extracorporeal photopheresis is effective in producing meaningful responses in patients with Sézary syndrome. A single-center, 5-year retrospective analysis was performed on our patients with Sézary syndrome who received extracorporeal photopheresis using a novel protocol. Thirteen patients were treated with extracorporeal photopheresis consistently for a minimum of 2 months.
View Article and Find Full Text PDFAlthough mycosis fungoides (MF) is typically an indolent disease, patients with advanced-stage disease (stages IIB-IVB), including Sézary syndrome (SS), often have a poor outcome. A 31-year, retrospective analysis of our cutaneous lymphoma database, of 297 patients with MF and SS, was undertaken to study long-term outcomes and identify clinical predictors of outcome in patients with advanced-stage disease (ASD, n = 92) and large cell transformation (LCT, n = 22). Two-thirds of patients with ASD presented with de novo ASD.
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