Publications by authors named "Susanth Alapati"
Background: There are concerns that biocide skin and mucous membrane decolonisation, which is widely used to prevent health-care-associated infections in intensive care units (ICUs), might select for multidrug-resistant pathogens. We aimed to evaluate the effects of de-escalating from universal to targeted skin and nasal decolonisation on Staphylococcus epidermidis bloodstream infections (SE-BSI).
Methods: We did a retrospective, before-after-control-impact time-series analysis and longitudinal genotypic study in two ICUs with divergent decolonisation practice in tertiary care hospitals of adjacent health boards in Scotland, UK.
Article Synopsis
- Extended spectrum β-lactamase-producing Escherichia coli is a significant cause of hospital-acquired bloodstream infections, particularly in regions with effective antimicrobial management.
- A study at a tertiary hospital in North-East Scotland analyzed bloodstream infection isolates from 2010 to 2020 to assess their genetic structure and resistance patterns after implementing a new antimicrobial stewardship policy called "4C."
- The results revealed that while ST131 E. coli showed a stable presence and reduced resistance over time, its overall fitness declined, suggesting changes in bacterial behavior despite similar virulence factor levels.
In recent years, high-throughput technologies have facilitated the widespread use of metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC). As a result, the primary goal of this systematic review is to identify and evaluate metabolite biomarkers and their pathways for OSCC that featured consistently across studies despite methodological variations. Six electronic databases (Medline, Cochrane, Web of Science, CINAHL, ProQuest, and Embase) were reviewed for the longitudinal studies involving OSCC patients and metabolic marker analysis (in accordance with PRISMA 2020).
View Article and Find Full Text PDFCandida albicans is frequently identified as a colonizer of the oral cavity in health and has recently been termed a "keystone" commensal due to its role on the bacterial communities. However, the role that C. albicans plays in such interactions is not fully understood.
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