Efficacy and Safety of a Tri-Valent Ready-to-Use Porcine Circovirus Type 2a, and Vaccine in Weaned Pigs.

: This study describes multiple trials demonstrating the safety and efficacy of a tri-valent vaccine against diseases caused by Porcine Circovirus Types 2a and 2d (PCV2a, PCV2d), , and . : For each of the PCV2a and PCV2d onset of immunity (OOIs) and duration of immunity (DOI) studies, 25 pigs were vaccinated with a tri-valent vaccine and 25 with placebo. After dual challenge with PCV2a and porcine reproductive and respiratory virus (PRRSV) (OOI) or single challenge with PCV2d (OOI and DOI), respectively, viremia and lymphoid depletion data were collected.

Quadrivalent neuraminidase RNA particle vaccine protects pigs against homologous and heterologous strains of swine influenza virus infection.

Influenza A virus in swine (IAV-S) continues to cause significant negative impact to both sows and growing pigs. The viral hemagglutinin (HA) and neuraminidase (NA) genes continue to evolve with HA diversifying at a faster rate than NA. Depending on country, whole inactivated virus (WIV) commercial and autogenous vaccines, as well as veterinary prescription vaccines targeting HA, are currently available.

NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene.

We have identified Severe Combined Immunodeficiency (SCID) in a line of Yorkshire pigs at Iowa State University. These SCID pigs lack B-cells and T-cells, but possess Natural Killer (NK) cells. This SCID phenotype is caused by recessive mutations in the Artemis gene.

Salmonella enterica serovar Typhimurium-infected pigs with different shedding levels exhibit distinct clinical, peripheral cytokine and transcriptomic immune response phenotypes.

Foodborne salmonellosis costs the US $2.7 billion/year, including $100.0 million in annual losses to pork producers.

Organic barn dust extract exposure impairs porcine macrophage function in vitro: implications for respiratory health.

Respiratory diseases are responsible for a significant amount of animal morbidity and mortality in the swine industry, including the majority of nursery and grower/finisher deaths. Innate immunity, including the maintenance of lung macrophage health and function, is an important defense mechanism against respiratory pathogens and their associated losses. Chronic exposure of swine industry workers to airborne barn dust results in significant predisposition to airway diseases and impairment of alveolar macrophage (AMφ) function.

Distinct peripheral blood RNA responses to Salmonella in pigs differing in Salmonella shedding levels: intersection of IFNG, TLR and miRNA pathways.

Transcriptomic analysis of the response to bacterial pathogens has been reported for several species, yet few studies have investigated the transcriptional differences in whole blood in subjects that differ in their disease response phenotypes. Salmonella species infect many vertebrate species, and pigs colonized with Salmonella enterica serovar Typhimurium (ST) are usually asymptomatic, making detection of these Salmonella-carrier pigs difficult. The variable fecal shedding of Salmonella is an important cause of foodborne illness and zoonotic disease.